白塞病中多形核白细胞的功能
Polymorphonuclear leucocyte function in Behçet's disease.
作者信息
Sobel J D, Haim S, Obedeanu N, Meshulam T, Merzbach D
出版信息
J Clin Pathol. 1977 Mar;30(3):250-3. doi: 10.1136/jcp.30.3.250.
Polymorphonuclear leucocyte function was investigated in 19 patients with active Behçet's disease. Spontaneous free leucocyte migration was found to be significantly reduced, yet after stimulation the leucocyte's chemotactic activity was considerably increase (p less than 0-05) when compared to control leucocytes. Control leucocytes migrated more rapidly when incubated in serum taken from patients with Behçet's disease (p less than 0-005). The enhanced chemotactic activity in Bechçet's disease appears to be due to both serum and intrinsic leucocyte factors. Spontaneous nitroblue tetrazolium reduction was found to be normal, although after stimulation leucocyte nitroblue tetrazolium reduction was lower than in the control group (P less than 0-025), as was leucocyte oxygen utilisation. It is suggested that the hyperreactive cellular inflammatory response that characterises Behçet's disease may be due to increased chemotactic activity and minor alterations in functional metabolic activity of leucocytes.
对19例活动期白塞病患者的多形核白细胞功能进行了研究。发现自发的白细胞游走显著减少，但与对照白细胞相比，刺激后白细胞的趋化活性显著增加（p<0.05）。当在取自白塞病患者的血清中孵育时，对照白细胞游走得更快（p<0.005）。白塞病中趋化活性增强似乎是由于血清和白细胞内在因素共同作用。发现自发的硝基蓝四氮唑还原正常，尽管刺激后白细胞硝基蓝四氮唑还原低于对照组（P<0.025），白细胞氧利用情况也是如此。提示以白塞病为特征的高反应性细胞炎症反应可能是由于趋化活性增加以及白细胞功能代谢活性的轻微改变所致。
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