Wu Jialin, Zhang Chaojin, Cao Qiang, Xuan Wei, Huai Xiaorong, Zhou Jie, Tian Jie
Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Key Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, China.
Front Aging Neurosci. 2025 May 30;17:1570428. doi: 10.3389/fnagi.2025.1570428. eCollection 2025.
Programmed death receptor 1 (PD-1), encoded by the PDCD1 gene, functions as a pivotal immunosuppressive molecule. Neurodegenerative diseases (NDDs) encompass a diverse array of neurological disorders that adversely impact the lives of millions of individuals globally. The current study discusses the impacts of PD-L1/PD-1 signaling on NDDs.
A comprehensive online search was conducted using the Web of Science Core Collection database (WOSCC), with a limited time frame set from 2004 to 2023. Data were analyzed with CiteSpace, VOSviewer, and bibliometric package to explore trends in research output, key authors, institutions, journals, and thematic developments.
This study analyzed 366 publications within the field of PD-L1/PD-1 and NDDs. During 2004-2023, there's an overall upward trajectory in the number of publications as the years progressed. The United States has a significant influence in this field, accounting for the highest number of publications. It also boasts the top two authors, six of the top 10 journals, and four of the top five institutions in terms of article count. Keyword burst analysis identified EAE, Parkinson's disease, adaptive immunity, immune checkpoint blockade, and cerebrospinal fluid are research hotspots in recent years.
This field has garnered increasing research attention, with the United States being the primary contributor. Recent studies have concentrated on the mechanisms through which PD-L1/PD-1 influences NDDs, and research into cerebrospinal fluid may persist as a focal point in the years to come. While the neuroprotective vs. neurodegenerative effects of PD-L1/PD-1 signaling remain controversial, this pathway represents a promising diagnostic and therapeutic target for NDDs.
程序性死亡受体1（PD-1）由PDCD1基因编码，是一种关键的免疫抑制分子。神经退行性疾病（NDDs）涵盖了一系列多样的神经系统疾病，对全球数百万个体的生活产生了不利影响。本研究探讨了PD-L1/PD-1信号通路对神经退行性疾病的影响。
利用科学网核心合集数据库（WOSCC）进行全面的在线搜索，设定的时间范围为2004年至2023年。使用CiteSpace、VOSviewer和文献计量软件包对数据进行分析，以探究研究产出、关键作者、机构、期刊和主题发展的趋势。
本研究分析了366篇关于PD-L1/PD-1与神经退行性疾病领域的出版物。在2004年至2023年期间，随着时间的推移，出版物数量总体呈上升趋势。美国在该领域具有重大影响力，出版物数量最多。就文章数量而言，美国还拥有前两位的作者、前十期刊中的六种以及前五机构中的四个。关键词突现分析确定实验性自身免疫性脑脊髓炎（EAE）、帕金森病、适应性免疫、免疫检查点阻断和脑脊液是近年来的研究热点。
该领域已获得越来越多的研究关注，美国是主要贡献者。近期研究集中在PD-L1/PD-1影响神经退行性疾病的机制上，对脑脊液的研究可能在未来几年仍将是一个重点。虽然PD-L1/PD-1信号通路的神经保护与神经退行性作用仍存在争议，但该通路是神经退行性疾病一个有前景的诊断和治疗靶点。
