Bathina Navya, Ganni Sadhika, Kolalapudi Seetharam A, Konala Subhashini, Dharavath Kalyan, Reddy Mandem T K
Department of Dermatology, Venereology, and Leprosy, GSL Medical College and General Hospital, Rajahmahendravaram, Andhra Pradesh, India.
Indian Dermatol Online J. 2024 Jun 10;15(4):612-615. doi: 10.4103/idoj.idoj_966_23. eCollection 2024 Jul-Aug.
In vitiligo, there is a significant decrease in melanocytes and melanin. The decrease in melanin causes oxidative stress, with a chance of causing metabolic syndrome. Hence, there is a need to look for metabolic syndrome in vitiligo.
To estimate the prevalence of metabolic syndrome in vitiligo patients and to evaluate the relationship between the severity and progression of vitiligo and metabolic syndrome.
A hospital-based cross-sectional study was conducted on 178 vitiligo cases and 178 controls who were age- and sex-matched. The type of vitiligo, stability by vitiligo disease activity score (VIDA), and severity by vitiligo area severity index (VASI) were noted. The waist circumference, blood pressure, fasting lipid profile, and fasting blood sugar were measured for cases and controls. Metabolic syndrome was diagnosed based on Harmonization Asian criteria.
The mean age in cases was 34.38 years, and in controls, it was 35.67 years. The majority were females in both cases (52.2%) and controls (55.6%). Most have a VIDA score of 2+ (41.6%). The mean VASI score was 2.54. The percentage of metabolic syndrome was higher in cases (36%) compared to controls (24.2%) ( = 0.015). The mean age was lower in vitiligo cases with metabolic syndrome (38.83 years) compared to controls with metabolic syndrome (43.14 years). Metabolic syndrome was more frequent in the vitiligo vulgaris type (48.9%) than in acral and segmental vitiligo. Metabolic syndrome was more common in patients with high VIDA (45%) and VASI (52.3%) scores compared to patients with low VIDA (25%) and VASI (27.3%) scores.
It is a hospital-based study, so controls were not from the general population.
The prevalence of metabolic syndrome was higher in vitiligo patients compared to controls, and it was higher in patients with active and severe disease. Screening and close monitoring of vitiligo patients help in the early diagnosis of metabolic syndrome and reduce the risk of cardiovascular disease.
在白癜风患者中，黑素细胞和黑色素显著减少。黑色素减少会导致氧化应激，进而有可能引发代谢综合征。因此，有必要在白癜风患者中筛查代谢综合征。
评估白癜风患者中代谢综合征的患病率，并评估白癜风的严重程度和进展与代谢综合征之间的关系。
开展了一项基于医院的横断面研究，纳入178例白癜风患者及178例年龄和性别匹配的对照。记录白癜风的类型、根据白癜风疾病活动评分（VIDA）判断的稳定性以及根据白癜风面积严重程度指数（VASI）判断的严重程度。测量病例组和对照组的腰围、血压、空腹血脂谱和空腹血糖。根据亚洲协调标准诊断代谢综合征。
病例组的平均年龄为34.38岁，对照组为35.67岁。病例组（52.2%）和对照组（55.6%）中大多数为女性。大多数患者的VIDA评分为2+（41.6%）。平均VASI评分为2.54。病例组中代谢综合征的比例（36%）高于对照组（24.2%）（P = 0.015）。患有代谢综合征的白癜风患者的平均年龄（38.83岁）低于患有代谢综合征的对照组（43.14岁）。寻常型白癜风患者中代谢综合征更为常见（48.9%），而非肢端型和节段型白癜风。与VIDA评分低（25%）和VASI评分低（27.3%）的患者相比，VIDA评分高（45%）和VASI评分高（52.3%）的患者中代谢综合征更为常见。
这是一项基于医院的研究，因此对照组并非来自普通人群。
白癜风患者中代谢综合征的患病率高于对照组，且在病情活跃和严重的患者中更高。对白癜风患者进行筛查和密切监测有助于早期诊断代谢综合征并降低心血管疾病风险。
