Lewis R A, Fleming J S
Br J Dis Chest. 1985 Oct;79(4):361-7. doi: 10.1016/0007-0971(85)90069-5.
The fractional deposition from an Inspiron 'Mini-Neb' jet nebulizer was assessed in six normal and two asthmatic subjects using technetium-99m-labelled millimicrospheres of human serum albumin suspended in saline. Sixty-six per cent of activity was retained in the apparatus tubing, 20% exhaled, 2% deposited in the mouth and 12% was retained in the lungs. The nebulizer fractional deposition therefore differs from the findings reported for a metered dose inhaler (Newman et al. 1981; Spiro et al. 1984), where 80-85% of particles leaving the cannister deposits in the mouth, and only 5-10% in the apparatus. The lung fraction from a nebulizer is, however, similar to the 9-11% from an MDI.
使用悬浮于盐水中的锝-99m标记的人血清白蛋白毫微球，对6名正常受试者和2名哮喘患者进行了Inspiron“Mini-Neb”喷射雾化器的颗粒沉积分数评估。66%的活性物质保留在仪器管道中，20%呼出，2%沉积在口腔，12%保留在肺部。因此，雾化器的颗粒沉积分数与计量吸入器的研究结果不同（Newman等人，1981年；Spiro等人，1984年），计量吸入器中离开药罐的颗粒80-85%沉积在口腔，仅5-10%沉积在仪器中。然而，雾化器的肺部沉积分数与计量吸入器的9-11%相似。
