来自眼部感染的化疗化合物和棘阿米巴原虫。
Chemotherapeutic compounds and Acanthamoebae from eye infections.
作者信息
Nagington J, Richards J E
出版信息
J Clin Pathol. 1976 Jul;29(7):648-51. doi: 10.1136/jcp.29.7.648.
Abstract
The amoebicidal and amoebistatic action in vitro of 24 compounds was tested on two strains of Acanthamoeba, A. polyphaga and A. castellanii, isolated from eye infections in this country. For comparison, the Ryan strain of A. castellanii and Naegleria gruberi L-1 were also examined. Nine compounds showed sufficient activity to merit further consideration, ie, acriflavine, proflavine, hydroxystilbamidine isethionate, paromomycin, miconazole, amphoterin, neomycin, polymyxin, and the last two combined in Neosporin.
摘要
在体外对从该国眼部感染中分离出的两株棘阿米巴（多噬棘阿米巴和卡氏棘阿米巴）测试了24种化合物的杀阿米巴和抑阿米巴作用。作为对照，还检测了卡氏棘阿米巴的Ryan株和格氏耐格里阿米巴L-1。九种化合物表现出足够的活性，值得进一步研究，即吖啶黄、黄原素、羟乙磺酸羟基二脒替、巴龙霉素、咪康唑、两性霉素、新霉素、多粘菌素，以及最后两种组合而成的新霉素软膏。
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