Srivastava Santosh Kumar, Foo Guo Wei, Aggarwal Nikhil, Chang Matthew Wook
NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore.
Synthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Biotechnol Notes. 2024 Jan 5;5:8-12. doi: 10.1016/j.biotno.2024.01.001. eCollection 2024.
Organ-on-chip (OOC) technology is an innovative approach that reproduces human organ structures and functions on microfluidic platforms, offering detailed insights into intricate physiological processes. This technology provides unique advantages over conventional in vitro and in vivo models and thus has the potential to become the new standard for biomedical research and drug screening. In this mini-review, we compare OOCs with conventional models, highlighting their differences, and present several applications of OOCs in biomedical research. Additionally, we highlight advancements in OOC technology, particularly in developing multiorgan systems, and discuss the challenges and future directions of this field.
器官芯片（OOC）技术是一种创新方法，可在微流控平台上再现人体器官结构和功能，为深入了解复杂的生理过程提供详细见解。与传统的体外和体内模型相比，该技术具有独特优势，因此有潜力成为生物医学研究和药物筛选的新标准。在本综述中，我们将器官芯片与传统模型进行比较，突出它们的差异，并介绍器官芯片在生物医学研究中的一些应用。此外，我们还强调了器官芯片技术的进展，特别是在开发多器官系统方面，并讨论了该领域的挑战和未来方向。
