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[高分散性锌粉给药期间小鼠肝脏中含磷代谢物水平的³¹P-核磁共振研究]

[31P-NMR study of the levels of phosphorus-containing metabolites in the mouse liver during administration of highly dispersed zinc powder].

作者信息

Fatkullina L D, Dubinskiĭ V Z, Glushchenko N N, Sibel'dina L A, Fedorov Iu I

出版信息

Biofizika. 1985 Jul-Aug;30(4):650-4.

PMID:4052468
Abstract

The content of phosphor-containing metabolites as regards inorganic phosphate of tissues of the mouse liver after injection of zinc highly dispersed powder at the dose of 5 mg/kg has been established with quantitative calculation of 31P-NMR spectra. A decrease in the relative level of phosphor-containing metabolites in the liver regeneration on the first day after partial hepatectomy has been observed. It has been shown that the relative level of phosphor-containing metabolites after injection more decreased during the first two days after operation. The observed changes of P-compounds metabolites in the liver after injection of zinc highly dispersed powder are related to its stimulation effect on metabolism of sugar and phospholipids and on the cell respiratory process.

摘要

通过对31P-NMR谱进行定量计算,确定了以5mg/kg剂量注射高度分散锌粉后小鼠肝脏组织中含磷代谢物的无机磷酸盐含量。观察到部分肝切除术后第一天肝脏再生过程中含磷代谢物的相对水平下降。结果表明,注射后含磷代谢物的相对水平在术后前两天下降得更多。注射高度分散锌粉后肝脏中P化合物代谢物的观察变化与其对糖和磷脂代谢以及细胞呼吸过程的刺激作用有关。

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