Wilkinson D A, Nagle J F
Biochemistry. 1979 Sep 18;18(19):4244-9. doi: 10.1021/bi00586a032.
Volumes of lipid dispersions as a function of temperature have been measured for two different kinds of binary mixtures of lecithins, (1) DMPC and DSPC and (2) DMPC and DC20PC. Emphasis was placed on DMPC-rich compositions so as to resolve ambiguities regarding solid-phase immiscibility in DMPC-DSPC mixtures. Special attention has been paid to problems of equilibration in the low-temperature phase and to methods of mixing the lipids. We find that there is no solid-solid immiscibility in DMPC-DSPC mixtures, although this system is close to exhibiting such immiscibility, and that DMPC-DC20PC mixtures exhibit pronounced solid immiscibility.
已针对两种不同的卵磷脂二元混合物测量了脂质分散体体积随温度的变化情况，这两种混合物分别是：（1）二肉豆蔻酰磷脂酰胆碱（DMPC）和二硬脂酰磷脂酰胆碱（DSPC），以及（2）二肉豆蔻酰磷脂酰胆碱（DMPC）和二油酰磷脂酰胆碱（DC20PC）。重点关注富含DMPC的组合物，以解决DMPC - DSPC混合物中固相不混溶的模糊问题。特别关注了低温相中的平衡问题以及脂质混合方法。我们发现，DMPC - DSPC混合物中不存在固 - 固不混溶现象，尽管该体系接近呈现这种不混溶现象，并且DMPC - DC20PC混合物表现出明显的固相不混溶现象。
