Vijila N S, Abraham Merin K, Rajeevan Greeshma, Indongo Geneva, Kala Arathy B, George Sony
Department of Chemistry, School of Physical and Mathematical Sciences, University of Kerala, Kariavattom Campus, Thiruvananthapuram, Kerala, 695581, India.
J Fluoresc. 2025 Jun 18. doi: 10.1007/s10895-025-04400-0.
Serotonin, a neurotransmitter and also a biomarker for Alzheimer's as well as Carcinoid Syndrome. It has two important roles in the human body - central as well as peripheral. In the central nervous system, it acts as a neurotransmitter and controls all the brain functions and as a peripheral hormone, it controls the functions of several organs in the body. Herein, we developed a Europium dipicolinic acid (EuDPA) based lanthanide luminescent complex with bright red fluorescence. This fluorescence is further used for the detection of Serotonin (ST). On adding ST, the fluorescence of the probe is quenched. Also, the developed probe shows good selectivity towards other neurotransmitters & co-existing biomolecules. A LoD of 0.99 nM is achieved with this probe. Sensing based on paper-strip was done to check the practicability of the probe, and a real sample analysis was also conducted from spiked human serum/urine samples.
血清素，一种神经递质，也是阿尔茨海默病和类癌综合征的生物标志物。它在人体中具有两个重要作用——中枢作用和外周作用。在中枢神经系统中，它作为神经递质发挥作用，控制所有脑功能；作为外周激素，它控制身体多个器官的功能。在此，我们开发了一种基于二吡啶甲酸铕（EuDPA）的具有亮红色荧光的镧系发光配合物。这种荧光进一步用于血清素（ST）的检测。加入ST后，探针的荧光被淬灭。此外，所开发的探针对其他神经递质和共存生物分子显示出良好的选择性。该探针实现了0.99 nM的检测限。基于纸条的传感用于检查探针的实用性，并且还对加标的人血清/尿液样本进行了实际样品分析。
