Yazew Birhaneslasie Gebeyehu, Shitu Workineh Tamir, Salih Mohammed Hassen, Aynalem Zewdu Bishaw, Agazhu Haile Workye, Endalew Daniel Adane
Department of Nursing, College of Medicine and Health Science, Injibara University, Injibara, Ethiopia.
Department of Medical Laboratory Science, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia.
PLoS One. 2025 Jun 18;20(6):e0324530. doi: 10.1371/journal.pone.0324530. eCollection 2025.
Heart failure (HF) is a major clinical condition contributing to high morbidity, mortality, and healthcare burden. Depression is increasingly recognized as a nontraditional risk factor for HF. However, data on its prevalence among HF patients in Ethiopia remain limited. This study aimed to estimate the pooled prevalence of depression in Ethiopian HF patients.
The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, using data abstraction from various electronic sources (PubMed, Web of Science, Google Scholar, Scopus, Science direct, African journal, and online University repositories studies). Studies reporting the prevalence of depression among heart failure patients found until 28th November, 2024 were included. Analysis was conducted using STATA version 17 software, with assessment of heterogeneity and publication bias. A random-effects meta-analysis model was used to estimate the pooled prevalence of depression.
This study revealing a pooled prevalence of depression among Heart failure patients in Ethiopia is 43.93%. Subgroup analyses based on region, type of institution, and sampling method showed different prevalence rates: the Southern Nations, Nationalities, and Peoples' Region had the highest rate at 60.13%, while Addis Ababa had the lowest at 35.18%. In terms of study institution types, teaching hospitals reported the highest prevalence at 46.81%, whereas referral hospitals showed the lowest rate at 31.05%. When considering sampling techniques, consecutive sampling yielded the highest prevalence at 55.09%, compared to just 15.40% for systematic random sampling. The analysis indicated a publication bias (p = 0.003), which warranted the use of trim and fill methods.
The rate of depression among heart failure patients in Ethiopia is notably high, highlighting the necessity for targeted interventions from the Ministry of Health to tackle this concern. It is essential to create multi-sectorial strategies that offer context-specific solutions, such as rehabilitation programs, to help reduce depression in heart failure patients. The review protocol was registered in PROSPERO ID: CRD42023405077.
心力衰竭（HF）是一种主要的临床病症，导致高发病率、高死亡率和沉重的医疗负担。抑郁症越来越被认为是心力衰竭的非传统风险因素。然而，埃塞俄比亚心力衰竭患者中抑郁症患病率的数据仍然有限。本研究旨在估计埃塞俄比亚心力衰竭患者抑郁症的合并患病率。
本研究遵循系统评价和Meta分析的首选报告项目指南，使用从各种电子来源（PubMed、科学网、谷歌学术、Scopus、科学直接数据库、非洲期刊和在线大学知识库研究）提取的数据。纳入截至2024年11月28日报告心力衰竭患者抑郁症患病率的研究。使用STATA 17软件进行分析，评估异质性和发表偏倚。采用随机效应Meta分析模型估计抑郁症的合并患病率。
本研究显示埃塞俄比亚心力衰竭患者抑郁症的合并患病率为43.93%。基于地区、机构类型和抽样方法的亚组分析显示了不同的患病率：南方民族、民族和人民地区患病率最高，为60.13%，而亚的斯亚贝巴患病率最低，为35.18%。就研究机构类型而言，教学医院报告的患病率最高，为46.81%，而转诊医院的患病率最低，为31.05%。在考虑抽样技术时，连续抽样的患病率最高，为55.09%，而系统随机抽样仅为15.40%。分析表明存在发表偏倚（p = 0.003），这使得有必要使用修剪和填充方法。
埃塞俄比亚心力衰竭患者的抑郁症发病率显著较高，这突出了卫生部采取针对性干预措施解决这一问题的必要性。制定多部门战略以提供针对具体情况的解决方案，如康复计划，对于帮助降低心力衰竭患者的抑郁症至关重要。该综述方案已在PROSPERO登记，登记号：CRD42023405077。
