Pedersen S
Clin Allergy. 1985 Sep;15(5):473-8. doi: 10.1111/j.1365-2222.1985.tb02297.x.
In a double blind cross-over study the bronchodilator response after eight different modes of inhalation of terbutaline from a pressurized aerosol with a tube spacer was assessed in fifteen asthmatic children. Slow inspiratory flow rates (15-30 l/min) were found to be associated with a statistically significant increase in response when compared with flow rates higher than 70 l/min (P less than 0.01). Tilting the head back during the inhalations and a breath-holding pause of 10 sec after the inhalation had no significant effect upon bronchodilation. In addition, bronchodilation was the same whether the children inhaled from RV or FRC, and whether they inhaled as deeply possible or only to about half the maximum volume. The results suggest that efforts should be made to develop a new and more simple set of instructions for the use of tube spacer aerosols.
在一项双盲交叉研究中，对15名哮喘儿童使用带储雾罐的压力定量气雾剂以8种不同吸入方式吸入特布他林后的支气管扩张反应进行了评估。结果发现，与高于70升/分钟的流速相比，缓慢吸气流速（15 - 30升/分钟）与反应的统计学显著增加相关（P小于0.01）。吸入过程中头部后仰以及吸入后屏气10秒对支气管扩张无显著影响。此外，儿童从残气量（RV）或功能残气量（FRC）吸入，以及尽可能深吸气或仅吸入至最大容量的一半左右时，支气管扩张情况相同。结果表明，应努力制定一套新的、更简单的使用储雾罐气雾剂的说明。
