Zhang Wei, Wang Mao-Shui, Zhang Jianguo, Gao Chunhai
Orthopaedic Medicine Center, Linyi People's Hospital, Shandong Second Medical University, Linyi, China.
Department of Lab Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, China.
Front Neurosci. 2025 Jun 4;19:1570726. doi: 10.3389/fnins.2025.1570726. eCollection 2025.
This case report discusses a 72-year-old male patient with Parkinson's disease, depression, and somatization disorder, presenting to the emergency department after a suspected overdose of clonazepam. The patient was discovered unconscious approximately 2.5 h after ingestion of over 30 tablets of clonazepam, in combination with an overdose of alprazolam and olanzapine. Despite initial challenges with gastric lavage, subsequent treatment involved supportive care, management of complications such as pneumonia, and renal replacement therapy, ultimately leading to recovery. This case highlights the complexities of managing overdoses, particularly those involving drugs with long half-lives, and highlights the challenges of treating elderly patients and the importance of supportive care in recovery.
本病例报告讨论了一名72岁男性患者，患有帕金森病、抑郁症和躯体化障碍，在疑似过量服用氯硝西泮后前往急诊科就诊。患者在服用30多片氯硝西泮以及过量服用阿普唑仑和奥氮平后约2.5小时被发现昏迷。尽管最初洗胃遇到困难，但后续治疗包括支持性护理、处理诸如肺炎等并发症以及肾脏替代治疗，最终患者康复。本病例突出了处理药物过量的复杂性，尤其是那些涉及半衰期长的药物的过量情况，并凸显了治疗老年患者的挑战以及支持性护理在康复中的重要性。
