Zack M B, Palange A V
Chest. 1985 Nov;88(5):669-75. doi: 10.1378/chest.88.5.669.
An outpatient pulmonary rehabilitation program was evaluated for evidence of patient improvement. All patients exercised on 4 LPM oxygen (O2). Inspiratory resistive loading (ventilatory muscle modality) was prescribed to achieve one-half of the patient's maximal inspiratory force at minute ventilation (VE) not greater than one-and-one half times resting VE. Walking (nonventilatory muscle exercise) was prescribed at work level requiring VE of 50 percent of maximum breathing capacity, if a ventilatory limit to exercise, or a work level set at 60 percent of VO2 maximum, if no ventilatory limit to exercise. Significant improvement was noted after rehabilitation in maximum workload, 12 min walk, and endurance both on room air (RA) and O2, as compared to pre-rehabilitation values. No improvement was noted in resting pulmonary function, gas exchange, exercise-induced hypoxemia or VO2 max. O2 increased work performance compared to values in the same patients on RA, both before and after rehabilitation, an effect possibly mediated by O2-induced reduction in submaximal VE.
对一项门诊肺康复计划进行评估，以寻找患者病情改善的证据。所有患者均在4升/分钟的氧气（O₂）支持下进行锻炼。规定采用吸气阻力负荷（通气肌肉训练方式），以使患者在分钟通气量（VE）时达到最大吸气力的一半，且不超过静息VE的1.5倍。若存在运动通气限制，则规定步行（非通气肌肉运动）的工作强度需达到最大呼吸能力的50%的VE；若不存在运动通气限制，则工作强度设定为最大摄氧量（VO₂）的60%。与康复前的值相比，康复后患者的最大工作量、12分钟步行距离以及在室内空气（RA）和氧气环境下的耐力均有显著改善。静息肺功能、气体交换、运动性低氧血症或最大摄氧量（VO₂ max）均未见改善。与相同患者在RA环境下的值相比，无论康复前后，氧气均能提高工作表现，这一效应可能是由氧气导致的次最大VE降低所介导的。
