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实验室误差对患者健康的影响:一例关于过度诊断及其继发医源性疾病的病例报告

The Impact of a Laboratory Error on a Patient's Well Being: A Case Report on Overdiagnosis and Its Consequent Iatrogenesis.

作者信息

Laranjeira Correia Luís, Ferreira Vieira Joana, Oliveira Neves Catarina, de Freitas Domingues Maria

机构信息

Family Medicine, Unidade de Saúde Familiar São Pedro da Cova, Unidade Local de Saúde Santo António, Porto, PRT.

Family Medicine, Unidade de Saúde Familiar São Pedro da Cova,Unidade Local de Saúde Santo António, Porto, PRT.

出版信息

Cureus. 2025 May 20;17(5):e84446. doi: 10.7759/cureus.84446. eCollection 2025 May.

Abstract

Overdiagnosis, resulting from excessive use of diagnostic tests, can lead to unnecessary treatments and negatively impact patients' quality of life. This case highlights the importance of prescribing tests based on the best scientific evidence to avoid emotional and financial harm to patients while promoting quaternary prevention. A 77-year-old woman, undergoing surveillance for a thyroid nodule, mistakenly underwent a urinary cytology test, which revealed a suspicious finding. Due to this incidental result, the Family Physician referred her to a Urology consultation to rule out urothelial cancer. The subsequent investigations included renal and pelvic CT scans, urethrocystoscopy, and repeated urinary cytology, all of which yielded negative results for malignancy. Throughout this process, the patient experienced anxiety, sadness, and loss of appetite, which also affected her family life. The test requested by the Family Physician was a non-cervicovaginal exfoliative cytology, which can encompass various types of cytology. However, due to a laboratory error, urinary cytology was performed instead of a fine-needle aspiration cytology (FNAC) of the thyroid. This mistake led to an unfounded suspicion of cancer, causing significant anxiety for the patient and her family. The cascade of invasive tests and the use of limited healthcare resources underscore the dangers of overdiagnosis and the challenge of maintaining healthcare system sustainability. This case illustrates the importance of quaternary prevention, encouraging a cautious approach to ordering diagnostic and therapeutic tests, as well as involving patients in informed decision-making regarding their health. The role of the Family Physician is crucial in understanding patients' concerns and needs, promoting a holistic, patient-centered approach to healthcare delivery.

摘要

过度诊断是由诊断测试的过度使用导致的,可能会导致不必要的治疗,并对患者的生活质量产生负面影响。本案例强调了根据最佳科学证据开具检查的重要性,以避免对患者造成情感和经济伤害,同时促进四级预防。一名77岁的女性因甲状腺结节接受监测,却误做了尿液细胞学检查,结果显示有可疑发现。由于这个偶然结果,家庭医生将她转诊至泌尿外科会诊以排除尿路上皮癌。随后的检查包括肾脏和盆腔CT扫描、尿道膀胱镜检查以及重复的尿液细胞学检查,所有这些检查的恶性结果均为阴性。在整个过程中,患者经历了焦虑、悲伤和食欲不振,这也影响了她的家庭生活。家庭医生要求的检查是一项非宫颈阴道脱落细胞学检查,它可以涵盖各种类型的细胞学检查。然而,由于实验室错误,进行的是尿液细胞学检查而非甲状腺细针穿刺抽吸活检(FNAC)。这个错误导致了毫无根据的癌症怀疑,给患者及其家人带来了极大的焦虑。一系列侵入性检查以及有限医疗资源的使用凸显了过度诊断的危险性以及维持医疗系统可持续性的挑战。本案例说明了四级预防的重要性,鼓励在开具诊断和治疗检查时采取谨慎态度,并让患者参与有关其健康的知情决策。家庭医生的作用对于理解患者的担忧和需求、促进以患者为中心的整体医疗服务方法至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/093f/12177551/3bd7e1c44c19/cureus-0017-00000084446-i01.jpg

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