Mosher D F, Fine D P, Moe J B, Kenyon R H, Ruch G L
J Infect Dis. 1977 Jun;135(6):985-9. doi: 10.1093/infdis/135.6.985.
We studied the coagulation and complement systems during Rocky Mountain spotted fever in Macaca mulatta experimentally infected with Rickettsia rickettsii. Ninety-one percent of monkeys infected intravenously with a high dose (10(6) plaque-forming units [pfu]) and 56% of monkeys infected with low doses (10(-1)-10(2) pfu) of R. rickettsii died after two to four days of illness. With the onset of fever and rickettsemia, animals developed hyperfibrinogenemia, mild thrombocytopenia, prolonged prothrombin and activated thromboplastin times, and increased serum fibrin/fibrinogen degradation products (FDP). Rickettsemia, thrombocytopenia, and FDP were greater in fatally ill monkeys than in survivors. Hemolytic titers of the second and third components of complement were not depressed except in a single surviving monkey that developed peripheral gangrenous ecchymoses at a time when both rickettsemia and agglutinating antibody were present. Thus, although activation and consumption of complement may occur during Rocky Mountain spotted fever, the hemostatic disturbances in fulminant infections seem to be a direct effect of the infectious vasculitis.
我们对实验感染立氏立克次体的食蟹猴感染落基山斑疹热期间的凝血和补体系统进行了研究。静脉注射高剂量（10⁶ 空斑形成单位 [pfu]）立氏立克次体的猴子中有91%，以及感染低剂量（10⁻¹ - 10² pfu）立氏立克次体的猴子中有56%在发病两到四天后死亡。随着发热和立克次体血症的出现，动物出现高纤维蛋白原血症、轻度血小板减少、凝血酶原时间和活化部分凝血活酶时间延长，以及血清纤维蛋白/纤维蛋白原降解产物（FDP）增加。致命患病猴子的立克次体血症、血小板减少和FDP比存活猴子更严重。除了一只存活猴子在出现立克次体血症和凝集抗体时发生外周坏疽性瘀斑外，补体第二和第三成分的溶血效价并未降低。因此，虽然落基山斑疹热期间可能会发生补体的激活和消耗，但暴发性感染中的止血障碍似乎是感染性血管炎的直接作用。
