Gonder J C, Kenyon R H, Pedersen C E
J Clin Microbiol. 1979 Nov;10(5):719-23. doi: 10.1128/jcm.10.5.719-723.1979.
A nonhuman primate model of Rocky Mountain spotted fever infection was developed in cynomolgus monkeys (Macaca fascicularis) infected by the subcutaneous route or by aerosol. Clinical responses, hematology and serum chemistry values, and pathological findings were similar to those found in humans ill with Rocky Mountain spotted fever. The clinical model was then used to test the efficacy of a killed Rocky Mountain spotted fever vaccine grown in chicken embryo cells. Monkeys were immunized with varying dilutions of the vaccine with a two-dose schedule and then challenged at 2 months with virulent Rickettsia rickettsii by the subcutaneous route or by aerosol. The undiluted vaccine totally protected monkeys against both challenges, even at extremely high doses.
通过皮下途径或气溶胶感染食蟹猴（猕猴）建立了落基山斑疹热感染的非人灵长类动物模型。临床反应、血液学和血清化学值以及病理结果与患落基山斑疹热的人类相似。然后使用该临床模型来测试在鸡胚细胞中培养的灭活落基山斑疹热疫苗的疗效。用不同稀释度的疫苗按两剂方案对猴子进行免疫，然后在2个月时通过皮下途径或气溶胶用强毒立氏立克次体进行攻击。即使在极高剂量下，未稀释的疫苗也能完全保护猴子免受两种攻击。
