食蟹猴中一种灭活落基山斑疹热疫苗的评估
Evaluation of a killed Rocky Mountain spotted fever vaccine in cynomolgus monkeys.
作者信息
Gonder J C, Kenyon R H, Pedersen C E
出版信息
J Clin Microbiol. 1979 Nov;10(5):719-23. doi: 10.1128/jcm.10.5.719-723.1979.
Abstract
A nonhuman primate model of Rocky Mountain spotted fever infection was developed in cynomolgus monkeys (Macaca fascicularis) infected by the subcutaneous route or by aerosol. Clinical responses, hematology and serum chemistry values, and pathological findings were similar to those found in humans ill with Rocky Mountain spotted fever. The clinical model was then used to test the efficacy of a killed Rocky Mountain spotted fever vaccine grown in chicken embryo cells. Monkeys were immunized with varying dilutions of the vaccine with a two-dose schedule and then challenged at 2 months with virulent Rickettsia rickettsii by the subcutaneous route or by aerosol. The undiluted vaccine totally protected monkeys against both challenges, even at extremely high doses.
摘要
通过皮下途径或气溶胶感染食蟹猴（猕猴）建立了落基山斑疹热感染的非人灵长类动物模型。临床反应、血液学和血清化学值以及病理结果与患落基山斑疹热的人类相似。然后使用该临床模型来测试在鸡胚细胞中培养的灭活落基山斑疹热疫苗的疗效。用不同稀释度的疫苗按两剂方案对猴子进行免疫，然后在2个月时通过皮下途径或气溶胶用强毒立氏立克次体进行攻击。即使在极高剂量下，未稀释的疫苗也能完全保护猴子免受两种攻击。
相似文献
1
Evaluation of a killed Rocky Mountain spotted fever vaccine in cynomolgus monkeys.食蟹猴中一种灭活落基山斑疹热疫苗的评估
J Clin Microbiol. 1979 Nov;10(5):719-23. doi: 10.1128/jcm.10.5.719-723.1979.
2
Effect of vaccination schedule on immune response of Macaca mulatta to cell culture-grown Rocky Mountain spotted fever vaccine.疫苗接种程序对猕猴针对细胞培养的落基山斑疹热疫苗免疫反应的影响。
J Clin Microbiol. 1976 Sep;4(3):253-7. doi: 10.1128/jcm.4.3.253-257.1976.
3
New assay of protective activity of Rocky Mountain spotted fever vaccines.落基山斑疹热疫苗保护活性的新检测方法。
J Clin Microbiol. 1976 Sep;4(3):309-11. doi: 10.1128/jcm.4.3.309-311.1976.
4
Comparison of three rocky mountain spotted fever vaccines.三种落基山斑疹热疫苗的比较。
J Clin Microbiol. 1975 Oct;2(4):300-4. doi: 10.1128/jcm.2.4.300-304.1975.
5
Rocky Mountain spotted fever vaccine in an animal model.落基山斑疹热疫苗在动物模型中的研究
J Clin Microbiol. 1983 Aug;18(2):321-6. doi: 10.1128/jcm.18.2.321-326.1983.
6
Reactogenicity, immunogenicity, and efficacy of a chick embryo cell-derived vaccine for Rocky Mountain spotted fever.一种鸡胚细胞源性落基山斑疹热疫苗的反应原性、免疫原性和效力
J Infect Dis. 1983 Nov;148(5):922-30. doi: 10.1093/infdis/148.5.922.
7
Rocky Mountain spotted fever vaccine: a regional need.落基山斑疹热疫苗：一项地区需求。
South Med J. 1984 Apr;77(4):447-9. doi: 10.1097/00007611-198404000-00009.
8
Preparation of Rocky Mountain spotted fever vaccine suitable for human immunization.制备适用于人体免疫的落基山斑疹热疫苗。
J Clin Microbiol. 1975 Jun;1(6):500-3. doi: 10.1128/jcm.1.6.500-503.1975.
9
Antibody response to Rocky Mountain spotted fever.对落基山斑疹热的抗体反应
J Clin Microbiol. 1976 May;3(5):513-8. doi: 10.1128/jcm.3.5.513-518.1976.
10
Rickettsia rickettsii Whole-Cell Antigens Offer Protection against Rocky Mountain Spotted Fever in the Canine Host.恙虫病东方体全细胞抗原在犬宿主中提供对落矶山斑点热的保护。
Infect Immun. 2019 Jan 24;87(2). doi: 10.1128/IAI.00628-18. Print 2019 Feb.
引用本文的文献
1
In silico construction of a multi-epitope vaccine (RGME-VAC/ATS-1) against the Rickettsia genus using immunoinformatics.利用免疫信息学对立克次氏体属进行多表位疫苗（RGME-VAC/ATS-1）的计算机模拟构建。
Mem Inst Oswaldo Cruz. 2025 Mar 21;120:e240201. doi: 10.1590/0074-02760240201. eCollection 2025.
2
Gaps and inconsistencies in the current knowledge and implementation of biosafety and biosecurity practices for rickettsial pathogens.当前关于立克次体病原体的生物安全和生物安保实践的知识和实施方面存在差距和不一致之处。
BMC Infect Dis. 2024 Feb 29;24(1):268. doi: 10.1186/s12879-024-09151-0.
3
Vaccine Design and Vaccination Strategies against Rickettsiae.针对立克次氏体的疫苗设计与接种策略
Vaccines (Basel). 2021 Aug 12;9(8):896. doi: 10.3390/vaccines9080896.
4
The neglected challenge: Vaccination against rickettsiae.被忽视的挑战：立克次氏体疫苗接种。
PLoS Negl Trop Dis. 2020 Oct 22;14(10):e0008704. doi: 10.1371/journal.pntd.0008704. eCollection 2020 Oct.
5
Recent research milestones in the pathogenesis of human rickettsioses and opportunities ahead.人类立克次体病发病机制的近期研究里程碑及未来机遇。
Future Microbiol. 2020 Jun;15(9):753-765. doi: 10.2217/fmb-2019-0266. Epub 2020 Jul 21.
6
Rickettsia rickettsii Whole-Cell Antigens Offer Protection against Rocky Mountain Spotted Fever in the Canine Host.恙虫病东方体全细胞抗原在犬宿主中提供对落矶山斑点热的保护。
Infect Immun. 2019 Jan 24;87(2). doi: 10.1128/IAI.00628-18. Print 2019 Feb.
本文引用的文献
1
Rickettsial diseases in the United States.美国的立克次体病。
Med Clin North Am. 1959 Sep;43:1507-35. doi: 10.1016/s0025-7125(16)34109-8.
2
Plaque assay for Rickettsia rickettsii.立氏立克次体的噬斑测定
J Bacteriol. 1969 May;98(2):398-402. doi: 10.1128/jb.98.2.398-402.1969.
3
The pathogenesis of Rocky Mountain spotted fever in monkeys, infected by inhalation.吸入感染的猴子患落基山斑疹热的发病机制。
Arch Pathol. 1967 Nov;84(5):486-94.
4
Rocky Mountain spotted fever: clinical and laboratory observations of monkeys after respiratory exposure.落基山斑疹热：猴子经呼吸道接触后的临床及实验室观察
J Infect Dis. 1966 Apr;116(2):243-55. doi: 10.1093/infdis/116.2.243.
5
Plaque formation in tissue cultures by Rickettsia rickettsi isolated directly from whole blood and tick hemolymph.从全血和蜱血淋巴中直接分离出的立氏立克次体在组织培养中形成斑块。
Infect Immun. 1972 Nov;6(5):736-8. doi: 10.1128/iai.6.5.736-738.1972.
6
A microagglutination technique for detection and measurement of rickettsial antibodies.一种用于检测和测量立克次氏体抗体的微量凝集技术。
Acta Virol. 1969 Jan;13(1):60-6.
7
Effect of vaccination schedule on immune response of Macaca mulatta to cell culture-grown Rocky Mountain spotted fever vaccine.疫苗接种程序对猕猴针对细胞培养的落基山斑疹热疫苗免疫反应的影响。
J Clin Microbiol. 1976 Sep;4(3):253-7. doi: 10.1128/jcm.4.3.253-257.1976.
8
Changes in blood serum constituents and hematologic values in Macaca mulatta with Rocky Mountain spotted fever.感染落基山斑疹热的恒河猴血清成分及血液学值的变化
Am J Vet Res. 1976 Jun;37(6):725-30.
9
Pathology of experimental Rocky Mountain spotted fever in rhesus monkeys.恒河猴实验性落基山斑疹热的病理学
Vet Pathol. 1976;13(1):69-77. doi: 10.1177/030098587601300108.
10
Preparation of Rocky Mountain spotted fever vaccine suitable for human immunization.制备适用于人体免疫的落基山斑疹热疫苗。
J Clin Microbiol. 1975 Jun;1(6):500-3. doi: 10.1128/jcm.1.6.500-503.1975.
Zotero 插件