Leles Lorena Cristina de Andrade, Castro Gabriel Abranches Dias, Milagres Jaderson Lopes, Paes Juliana Ribeiro, Rodrigues Leonarde Nascimento, de Carvalho Bittencourt Ricardo, da Costa Marcelo Moreira, Fernandes Sergio Antonio
Grupo de Química Supramolecular e Biomimética (GQSB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, MG 36570-900, Brazil.
Departamento de Ciências Exatas e da Terra, Universidade do Estado de Minas Gerais, Ubá, MG 36500-000, Brazil.
ACS Omega. 2025 Jun 4;10(23):24576-24586. doi: 10.1021/acsomega.5c01297. eCollection 2025 Jun 17.
The urgent need to replace fossil resources with renewable materials has driven the development of technologies to convert lignocellulosic biomass and its derived monosaccharides into valuable chemicals such as furfural (FF), 5-hydroxymethylfurfural (HMF), and levulinic acid (LA). This study employs a green and renewable solvent composed of 2-hydroxypropyl-βcyclodextrin (HP-β-CD) and LA, a supramolecular deep eutectic solvent (SupraDES), to synthesize FF from d-xylose. Microwave irradiation (MI) and -sulfonic acid calix[4]-arene (CX4SOH) were used as the heating method and organocatalyst, respectively. The SupraDES was characterized by using Raman spectroscopy, infrared spectroscopy, and thermogravimetric analysis. The results demonstrate the potential of this environmentally friendly system for efficient conversion of monosaccharides derived from lignocellulosic biomass, achieving a maximum yield of 70.6% of FF from d-xylose and 29.7% HMF from Dahlia tuber inulin, using heating via MI at 150 °C for 10 min, 150 mg of SupraDES, 3.0 mL of butyl acetate, and 1.0 mol % CX4SOH. The results of the techno-economic assessment of FF production showed highly positive financial outcomes, with strong economic viability and a quick capital payback.
用可再生材料替代化石资源的迫切需求推动了将木质纤维素生物质及其衍生的单糖转化为糠醛（FF）、5-羟甲基糠醛（HMF）和乙酰丙酸（LA）等有价值化学品的技术发展。本研究采用由2-羟丙基-β-环糊精（HP-β-CD）和LA组成的绿色可再生溶剂——一种超分子低共熔溶剂（SupraDES），从d-木糖合成FF。分别使用微波辐射（MI）和对磺酸杯[4]芳烃（CX4SOH）作为加热方法和有机催化剂。通过拉曼光谱、红外光谱和热重分析对SupraDES进行了表征。结果表明，该环境友好体系具有高效转化木质纤维素生物质衍生单糖的潜力，在150℃下通过MI加热10分钟、使用150mg SupraDES、3.0mL乙酸丁酯和1.0mol%CX4SOH的条件下，d-木糖转化为FF的最大产率达到70.6%，大丽菊块茎菊粉转化为HMF的产率达到29.7%。FF生产的技术经济评估结果显示出非常积极的财务成果，具有很强的经济可行性和快速的资本回收期。
