Schweitzer Justin, Ibach Mitch, Berdahl John, Daoud Myra, Daoud Yahya A, Kempinski Yitzi, Goldberg Jeffrey L
Vance Thompson Vision, Sioux Falls, SD, USA.
D&D Statistical Consultants, Oakland, CA, USA.
Clin Ophthalmol. 2025 Jun 17;19:1877-1884. doi: 10.2147/OPTH.S523260. eCollection 2025.
Assessment of disease and progression is one of the greatest unmet needs in glaucoma care. Moving visual field testing into the home stands to increase access and increase testing frequency to address these unmet needs. Here, we test a novel home-based app (Peripherex Visual Field Test or PRX-VFT) that leverages eye tracking in a short, "gamified" software environment, against in-office Humphrey Field Analyzer (HFA) data.
Observational, multicenter, open-label clinical trial in patients diagnosed with glaucoma, glaucoma suspect, or ocular hypertension.
A total of 190 PRX tests were performed with 97 on the left eye and 93 on the right eye, derived from 36 eyes of 19 patients who also had reliable, matched HFA data. Patients were 58% female with a mean (SD) age of 61.5 (11.9) years (range 26-78). Test-retest reliability was good, with interclass correlation coefficient of 0.7596. Detection of abnormal fields was excellent, with a sensitivity of 95.7% and a negative predictive value (NPV) of 98.27%. Detection of normal fields was very good, with a specificity of 79.26% and a positive predictive value (PPV) of 66.36%. Patients reported that compared to HFA, PRX-VFT was easier and more fun to complete.
In-home visual field testing using PRX-VFT on a patient's personal computer met its primary clinical trial endpoints, was feasible, and showed excellent statistical correlation to in-office HFA testing. PRX-VFT represents an opportunity for enhancing patient care at minimal additional equipment cost to the patient or healthcare system.
疾病评估和病情进展监测是青光眼治疗中尚未满足的最大需求之一。将视野检测引入家庭环境有望增加检测机会并提高检测频率，以满足这些未被满足的需求。在此，我们测试了一款新型的基于家庭的应用程序（Peripherex视野测试或PRX-VFT），该程序在一个简短的“游戏化”软件环境中利用眼动追踪技术，并与办公室使用的汉弗莱视野分析仪（HFA）数据进行对比。
对诊断为青光眼、青光眼疑似患者或高眼压症患者进行观察性、多中心、开放标签的临床试验。
共进行了190次PRX测试，其中左眼97次，右眼93次，数据来自19名患者的36只眼睛，这些患者同时也有可靠的、匹配的HFA数据。患者中女性占58%，平均（标准差）年龄为61.5（11.9）岁（范围26 - 78岁）。重测信度良好，组内相关系数为0.7596。异常视野的检测效果极佳，灵敏度为95.7%，阴性预测值（NPV）为98.27%。正常视野的检测效果很好，特异性为79.26%，阳性预测值（PPV）为66.36%。患者报告称，与HFA相比，PRX-VFT更容易完成且更有趣。
在患者个人电脑上使用PRX-VFT进行家庭视野检测达到了其主要临床试验终点，是可行的，并且与办公室HFA检测显示出极佳的统计学相关性。PRX-VFT为以患者或医疗系统最低的额外设备成本加强患者护理提供了机会。
