Keen M E, Murad T M, Cohen M I, Matthies H J
Hum Pathol. 1985 Nov;16(11):1147-52. doi: 10.1016/s0046-8177(85)80184-2.
Nine cases of benign breast disease in which mammograms had been false-positive were collected at Northwestern Memorial Hospital. In all but one case the patients had presented initially with questionable masses that required biopsies with requests for frozen section diagnoses. Included in the study were three cases of indurative mastopathy, three cases of fibrocystic disease with sclerosing adenosis, and one case each of sclerosing papillary proliferation, infarcted intraductal papilloma, and fat necrosis with foreign body giant cell reaction. The mammographic and histologic findings for all cases were reviewed. Indurative mastopathy is a poorly known entity with radiologic features highly suggestive of malignancy. As described previously (Cancer 47:561, 1981), the lesion consists of a central nidus of elastosis with irregular projections radiating into the adjacent breast tissue. Peripheral areas of the infarcted papilloma and sclerosing papillary proliferation could be confused with infiltrating carcinoma in frozen sections. Familiarity of pathologists with these lesions is essential for avoiding the overdiagnosis of carcinoma.
西北纪念医院收集了9例乳腺钼靶检查结果为假阳性的良性乳腺疾病病例。除1例患者外，其余患者最初均表现为可疑肿块，需要进行活检并要求进行冰冻切片诊断。该研究纳入了3例硬结性乳腺病、3例伴有硬化性腺病的纤维囊性疾病，以及硬化性乳头状增生、梗死性导管内乳头状瘤和伴有异物巨细胞反应的脂肪坏死各1例。对所有病例的乳腺钼靶和组织学检查结果进行了回顾。硬结性乳腺病是一种鲜为人知的疾病，其放射学特征高度提示恶性肿瘤。如先前所述（《癌症》47:561，1981），病变由弹性组织变性的中央病灶和向邻近乳腺组织放射状延伸的不规则突起组成。梗死性乳头状瘤和硬化性乳头状增生的周边区域在冰冻切片中可能与浸润性癌混淆。病理学家熟悉这些病变对于避免癌的过度诊断至关重要。
