血清型特异性单克隆抗体对沙眼衣原体细胞培养感染的中和作用。
Neutralization of Chlamydia trachomatis cell culture infection by serovar-specific monoclonal antibodies.
作者信息
Lucero M E, Kuo C C
出版信息
Infect Immun. 1985 Nov;50(2):595-7. doi: 10.1128/iai.50.2.595-597.1985.
Abstract
Seventeen monoclonal antibodies (MAs) were tested. Five of seven serovar-specific MAs from five different serovars and two of five subspecies-specific MAs showed neutralizing activity as well as serovar specificity. No species- or genus-specific MAs showed neutralizing activity. No neutralization occurred without complement. Results indicate neutralization was serovar specific and complement dependent.
摘要
对17种单克隆抗体（MAs）进行了测试。来自5个不同血清型的7种血清型特异性单克隆抗体中的5种以及5种亚种特异性单克隆抗体中的2种表现出中和活性以及血清型特异性。没有种属特异性单克隆抗体表现出中和活性。没有补体时不发生中和作用。结果表明中和作用具有血清型特异性且依赖补体。
相似文献
1
Neutralization of Chlamydia trachomatis cell culture infection by serovar-specific monoclonal antibodies.血清型特异性单克隆抗体对沙眼衣原体细胞培养感染的中和作用。
Infect Immun. 1985 Nov;50(2):595-7. doi: 10.1128/iai.50.2.595-597.1985.
2
Antibody-neutralizing activity against all urogenital Chlamydia trachomatis serovars in Chlamydia suis-infected pigs.猪衣原体感染猪中针对所有泌尿生殖道沙眼衣原体血清型的抗体中和活性。
FEMS Immunol Med Microbiol. 2011 Feb;61(1):125-8. doi: 10.1111/j.1574-695X.2010.00748.x. Epub 2010 Nov 8.
3
Production and characterization of monoclonal antibodies to Chlamydia trachomatis.沙眼衣原体单克隆抗体的制备与鉴定
Hybridoma (Larchmt). 2006 Oct;25(5):293-9. doi: 10.1089/hyb.2006.25.293.
4
Complement dependent in vitro neutralization of Chlamydia trachomatis by a subspecies-specific monoclonal antibody.一种亚种特异性单克隆抗体对沙眼衣原体的补体依赖性体外中和作用。
Med Microbiol Immunol. 1987;176(4):225-8. doi: 10.1007/BF00196690.
5
Monoclonal antibody against a genus-specific antigen of Chlamydia species: location of the epitope on chlamydial lipopolysaccharide.抗衣原体属特异性抗原的单克隆抗体：表位在衣原体脂多糖上的定位。
Infect Immun. 1984 May;44(2):306-14. doi: 10.1128/iai.44.2.306-314.1984.
6
Protective role of magnesium in the neutralization by antibodies of Chlamydia trachomatis infectivity.镁在沙眼衣原体感染性抗体中和中的保护作用。
Infect Immun. 1988 Apr;56(4):885-91. doi: 10.1128/iai.56.4.885-891.1988.
7
Protective monoclonal antibodies recognize epitopes located on the major outer membrane protein of Chlamydia trachomatis.保护性单克隆抗体识别位于沙眼衣原体主要外膜蛋白上的表位。
J Immunol. 1987 Jan 15;138(2):575-81.
8
[The immunochemical and biological properties of monoclonal antibodies to Chlamydia trachomatis].
Zh Mikrobiol Epidemiol Immunobiol. 1996 Jan-Feb(1):3-6.
9
Characterization of a neutralizing monoclonal antibody directed at variable domain I of the major outer membrane protein of Chlamydia trachomatis C-complex serovars.针对沙眼衣原体C复合血清型主要外膜蛋白可变区I的一种中和单克隆抗体的特性分析
Infect Immun. 1993 Apr;61(4):1365-70. doi: 10.1128/iai.61.4.1365-1370.1993.
10
Characterization of Chlamydia trachomatis antigens with monoclonal and polyclonal antibodies.用单克隆抗体和多克隆抗体对沙眼衣原体抗原进行鉴定。
Can J Microbiol. 1988 Feb;34(2):141-7. doi: 10.1139/m88-028.
引用本文的文献
1
Applying lessons from human papillomavirus vaccines to the development of vaccines against Chlamydia trachomatis.将人乳头瘤病毒疫苗的经验教训应用于沙眼衣原体疫苗的开发。
Expert Rev Vaccines. 2018 Nov;17(11):959-966. doi: 10.1080/14760584.2018.1534587. Epub 2018 Oct 20.
2
Protective Effect of Vaccine Promoted Neutralizing Antibodies against the Intracellular Pathogen .疫苗诱导的中和抗体对细胞内病原体的保护作用
Front Immunol. 2017 Dec 11;8:1652. doi: 10.3389/fimmu.2017.01652. eCollection 2017.
3
CD4+ T cells and antibody are required for optimal major outer membrane protein vaccine-induced immunity to Chlamydia muridarum genital infection.CD4+ T 细胞和抗体是最佳主要外膜蛋白疫苗诱导对鼠衣原体生殖道感染免疫所必需的。
Infect Immun. 2010 Oct;78(10):4374-83. doi: 10.1128/IAI.00622-10. Epub 2010 Jul 26.
4
Diagnosis and assessment of trachoma.沙眼的诊断与评估
Clin Microbiol Rev. 2004 Oct;17(4):982-1011, table of contents. doi: 10.1128/CMR.17.4.982-1011.2004.
5
Turkeys are protected from infection with Chlamydia psittaci by plasmid DNA vaccination against the major outer membrane protein.通过针对主要外膜蛋白进行质粒DNA疫苗接种，火鸡可免受鹦鹉热衣原体感染。
Clin Exp Immunol. 1999 Oct;118(1):49-55. doi: 10.1046/j.1365-2249.1999.01024.x.
6
High-level expression of Chlamydia psittaci major outer membrane protein in COS cells and in skeletal muscles of turkeys.鹦鹉热衣原体主要外膜蛋白在COS细胞和火鸡骨骼肌中的高水平表达。
Infect Immun. 1998 Nov;66(11):5494-500. doi: 10.1128/IAI.66.11.5494-5500.1998.
7
Human mannose-binding protein inhibits infection of HeLa cells by Chlamydia trachomatis.人甘露糖结合蛋白可抑制沙眼衣原体对HeLa细胞的感染。
Infect Immun. 1998 Apr;66(4):1607-12. doi: 10.1128/IAI.66.4.1607-1612.1998.
8
An N-linked high-mannose type oligosaccharide, expressed at the major outer membrane protein of Chlamydia trachomatis, mediates attachment and infectivity of the microorganism to HeLa cells.一种与沙眼衣原体主要外膜蛋白相关的N-连接高甘露糖型寡糖，介导该微生物对HeLa细胞的附着和感染性。
J Clin Invest. 1996 Dec 15;98(12):2813-8. doi: 10.1172/JCI119109.
9
Binding of the glycan of the major outer membrane protein of Chlamydia trachomatis to HeLa cells.沙眼衣原体主要外膜蛋白聚糖与HeLa细胞的结合。
Infect Immun. 1994 Jan;62(1):24-8. doi: 10.1128/iai.62.1.24-28.1994.
10
Primary human T-cell responses to the major outer membrane protein of Chlamydia trachomatis.人原代T细胞对沙眼衣原体主要外膜蛋白的反应。
Immunology. 1993 May;79(1):1-9.
本文引用的文献
1
The titration of trachoma and inclusion blennorrhoea viruses in cell cultures.沙眼病毒和包涵体性脓漏眼病毒在细胞培养中的滴定
J Gen Microbiol. 1960 Dec;23:613-9. doi: 10.1099/00221287-23-3-613.
2
Isotypes of mouse IgG--I. Evidence for 'non-complement-fixing' IgG1 antibodies and characterization of their capacity to interfere with IgG2 sensitization of target red blood cells for lysis by complement.小鼠IgG的同型——I. “非补体结合”IgG1抗体的证据及其干扰IgG2致敏靶红细胞被补体裂解能力的特性
Mol Immunol. 1980 Jun;17(6):699-710. doi: 10.1016/0161-5890(80)90139-x.
3
Localization of distinct surface antigens on Chlamydia trachomatis HAR-13 by immune electron microscopy with monoclonal antibodies.利用单克隆抗体通过免疫电子显微镜对沙眼衣原体HAR-13上不同表面抗原进行定位
Infect Immun. 1982 Dec;38(3):1273-8. doi: 10.1128/iai.38.3.1273-1278.1982.
4
Neutralization of Chlamydia trachomatis infectivity with antibodies to the major outer membrane protein.用针对主要外膜蛋白的抗体中和沙眼衣原体的感染性。
Infect Immun. 1982 Nov;38(2):745-54. doi: 10.1128/iai.38.2.745-754.1982.
5
Monoclonal antibodies to Chlamydia trachomatis: antibody specificities and antigen characterization.抗沙眼衣原体单克隆抗体：抗体特异性及抗原特性
J Immunol. 1982 Mar;128(3):1083-9.
6
Culture-independent diagnosis of Chlamydia trachomatis using monoclonal antibodies.使用单克隆抗体对沙眼衣原体进行非培养诊断。
N Engl J Med. 1984 May 3;310(18):1146-50. doi: 10.1056/NEJM198405033101803.
7
In vitro neutralization of Chlamydia trachomatis with monoclonal antibody to an epitope on the major outer membrane protein.用针对主要外膜蛋白上一个表位的单克隆抗体对沙眼衣原体进行体外中和。
Infect Immun. 1984 Nov;46(2):484-8. doi: 10.1128/iai.46.2.484-488.1984.
8
Sensitivity of immunofluorescence with monoclonal antibodies for detection of Chlamydia trachomatis inclusions in cell culture.用单克隆抗体进行免疫荧光检测细胞培养中沙眼衣原体包涵体的敏感性。
J Clin Microbiol. 1982 Jul;16(1):4-7. doi: 10.1128/jcm.16.1.4-7.1982.
9
The antigenic structure of proteins: a reappraisal.蛋白质的抗原结构：重新评估。
Annu Rev Immunol. 1984;2:67-101. doi: 10.1146/annurev.iy.02.040184.000435.
10
Immunotyping of Chlamydia trachomatis with monoclonal antibodies.用单克隆抗体对沙眼衣原体进行免疫分型
J Infect Dis. 1985 Oct;152(4):791-800. doi: 10.1093/infdis/152.4.791.
Zotero 插件