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电有机合成中的可重复性——神话与误解。

Reproducibility in Electroorganic Synthesis-Myths and Misunderstandings.

机构信息

Department of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.

出版信息

Angew Chem Int Ed Engl. 2021 Jun 25;60(27):14750-14759. doi: 10.1002/anie.202014544. Epub 2021 Mar 3.

Abstract

The use of electric current as a traceless activator and reagent is experiencing a renaissance. This sustainable synthetic method is evolving into a hot topic in contemporary organic chemistry. Since researchers with various scientific backgrounds are entering this interdisciplinary field, different parameters and methods are reported to describe the experiments. The variation in the reported parameters can lead to problems with the reproducibility of the reported electroorganic syntheses. As an example, parameters such as current density or electrode distance are in some cases more significant than often anticipated. This Minireview provides guidelines on reporting electrosynthetic data and dispels myths about this technique, thereby streamlining the experimental parameters to facilitate reproducibility.

摘要

电流作为一种无痕迹的活化剂和试剂正在经历复兴。这种可持续的合成方法正在成为当代有机化学的热门话题。由于具有不同科学背景的研究人员正在进入这个跨学科领域,因此报道了不同的参数和方法来描述实验。报道的参数的变化可能导致报道的电有机合成的重现性问题。例如,在某些情况下,电流密度或电极距离等参数比预期的更为重要。这篇综述提供了报告电合成数据的指南,并消除了有关该技术的一些误解,从而简化了实验参数以促进重现性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9a4/8251947/fb0775e0c588/ANIE-60-14750-g002.jpg

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