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1999年至2023年巴西透析调查:人口统计学、营养状况、原发性疾病和病毒血清学趋势

Brazilian Dialysis Survey from 1999 to 2023: trends in demographics, nutritional status, primary disease, and viral serology.

作者信息

Nerbass Fabiana B, Lima Helbert do N, Sesso Ricardo C, Lugon Jocemir R

机构信息

Fundação Pró-Rim, Joinville, SC, Brazil.

Universidade da Região de Joinville, Joinville, SC, Brazil.

出版信息

J Bras Nefrol. 2025 Jul-Sep;47(3):e20250036. doi: 10.1590/2175-8239-JBN-2025-0036en.

Abstract

INTRODUCTION

Since 1999, the annual Brazilian Dialysis Survey (BDS) has served as one of the essential primary data sources on the chronic dialysis population in Brazil. We aimed to analyze and report trends in demographic and clinical characteristics and the prevalence of positive viral serology among chronic dialysis patients from 1999 to 2023.

METHODS

We compared trends in sex distribution, age (elderly >65 years), primary causes of chronic kidney disease (CKD), nutritional status, and the prevalence of positive serology for hepatitis B, hepatitis C, and HIV. The Mann-Kendall test was used to evaluate trends across the entire study period, as well as in the first and second halves.

RESULTS

The prevalence of men on dialysis therapy increased slightly from 57% to 59%, while the proportion of elderly individuals rose from 24.9% in 2006 to 36.7% in 2023. Significant changes were observed in nutritional status, with prevalence changes in all categories. Hypertension remained the most prevalent primary cause of CKD; however, its prevalence declined over time, while that of diabetes increased and that of glomerulonephritis decreased. The prevalence of positive serology for hepatitis B and C virus has decreased substantially, whereas that of HIV increased.

CONCLUSION

Overtime, the most striking changes occurred in age, nutritional status, and viral serologies. During the analyzed period, the dialysis population in Brazil has become older and with a higher prevalence of overweight. On the other hand, the prevalence of positive serology for hepatitis B and mainly hepatitis C exhibited a dramatic fall.

摘要

引言

自1999年以来,巴西年度透析调查(BDS)一直是巴西慢性透析人群重要的主要数据来源之一。我们旨在分析并报告1999年至2023年期间慢性透析患者的人口统计学和临床特征趋势以及病毒血清学阳性的患病率。

方法

我们比较了性别分布、年龄(65岁以上老年人)、慢性肾脏病(CKD)的主要病因、营养状况以及乙肝、丙肝和艾滋病毒血清学阳性患病率的趋势。使用曼-肯德尔检验来评估整个研究期间以及前半期和后半期的趋势。

结果

接受透析治疗的男性患病率从57%略有上升至59%,而老年人的比例从2006年的24.9%升至2023年的36.7%。营养状况出现了显著变化,所有类别中的患病率都有改变。高血压仍然是CKD最常见的主要病因;然而,其患病率随时间下降,而糖尿病的患病率上升,肾小球肾炎的患病率下降。乙肝和丙肝病毒血清学阳性的患病率大幅下降,而艾滋病毒的患病率上升。

结论

随着时间的推移,最显著的变化发生在年龄、营养状况和病毒血清学方面。在分析期间,巴西的透析人群年龄增大,超重患病率更高。另一方面,乙肝尤其是丙肝血清学阳性的患病率大幅下降。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bc3/12187089/4f9e2f663fbe/2175-8239-jbn-47-3-e20250036-gf01.jpg

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