Loperena González Paola N, Karthigeyan Krithika P, Corry Jacqueline, Krishna Anurup, Hackenberg Ben, Sierra Beatriz, Kwiek Jesse J
Department of Microbiology and Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA.
Cellular, Molecular, and Biochemical Sciences Graduate Program, The Ohio State University, Columbus, Ohio, USA.
mBio. 2025 Aug 13;16(8):e0395424. doi: 10.1128/mbio.03954-24. Epub 2025 Jun 25.
Viruses regulate host processes to create cellular environments favorable to viral replication. At least 27 viruses that infect humans require host fatty acid synthase (FASN)-dependent fatty acid biosynthesis, including viruses from the , , and families. How could FASN activity and subsequent novo fatty acid production impact viral replication? FASN activity produces the fatty acid palmitate, which can be further metabolized into fatty acids that are used to form lipid droplets that can be used during viral assembly and budding, for beta-oxidation to generate ATP, and to create fatty acyl groups used for post-translational protein modification to change the subcellular localization of viral or host proteins. In this minireview, we outline the function of FASN, review the mechanisms linking virus replication and fatty acid biosynthesis, and consider the potential of FASN as a target for broad-spectrum antiviral drug development.
病毒调节宿主进程以创造有利于病毒复制的细胞环境。至少27种感染人类的病毒需要宿主脂肪酸合酶（FASN）依赖性脂肪酸生物合成，包括来自 、 、 和 家族的病毒。FASN活性以及随后的从头脂肪酸生成如何影响病毒复制？FASN活性产生脂肪酸棕榈酸酯，其可进一步代谢为脂肪酸，用于形成脂质滴，脂质滴可在病毒组装和出芽过程中使用，用于β-氧化以产生ATP，并用于产生用于翻译后蛋白质修饰的脂肪酰基，以改变病毒或宿主蛋白质的亚细胞定位。在本综述中，我们概述了FASN的功能，回顾了连接病毒复制和脂肪酸生物合成的机制，并考虑了FASN作为广谱抗病毒药物开发靶点的潜力。
