Wang Chengdong, Li Chengyao, Deng Linhua, Smith Meg Sutherland, Wei Rongping, Luo Li, Ling Shanshan, Liu Lixian, Nevitt Benjamin, Luo Bo, Li Wenjing, Li Caiwu, Yang Haidi, Wei Ming, Li Ti, Wu Kai, Qu Yuanyuan, Li Desheng
China Conservation and Research Center for the Giant Panda, Key Laboratory of SFGA on the Giant Panda, Chengdu 610081, China.
San Diego Zoo Wildlife Alliance, San Diego Zoo Global, 2920 Zoo Drive, San Diego, CA 92101, USA.
Vet Sci. 2025 Jun 3;12(6):544. doi: 10.3390/vetsci12060544.
The giant panda (), as an endemic and endangered species in China, has attracted much attention regarding its health issues. In recent years, certain diseases that affect giant pandas have gradually become important factors impacting their survival and breeding, including tumor diseases. Research on testicular cancer in giant pandas, in particular, has attracted the attention of scientific researchers because it poses a threat to individual reproductive function and population reproduction. This review systematically reviews the research progress of testicular cancer in giant pandas in recent years. Firstly, starting from case reports, the current research status of clinical manifestations, diagnostic methods and molecular mechanisms of testicular cancer in giant pandas was analyzed. Secondly, the commonly used treatment methods at present were discussed, including surgical resection, radiotherapy and chemotherapy, etc., and the advantages and disadvantages of these methods in practical applications were summarized. Furthermore, this article also conducts an in-depth exploration of the pathogenesis of testicular cancer in giant pandas, involving possible triggers such as genetic factors, environmental factors, and endocrine disorders. Based on the existing research results, this paper proposes a few future research directions, which will provide important support for the health management and population protection of giant pandas. Overall, although certain progress has been made in the research of testicular cancer in giant pandas, it still needs to be further deepened in order to provide a more powerful scientific basis for the healthcare and breeding of the endangered giant panda species.
大熊猫作为中国特有的濒危物种,其健康问题备受关注。近年来,一些影响大熊猫的疾病逐渐成为影响其生存和繁殖的重要因素,其中包括肿瘤疾病。特别是大熊猫睾丸癌的研究引起了科研人员的关注,因为它对个体生殖功能和种群繁殖构成威胁。本文系统综述了近年来大熊猫睾丸癌的研究进展。首先,从病例报告入手,分析了大熊猫睾丸癌的临床表现、诊断方法及分子机制的研究现状。其次,讨论了目前常用的治疗方法,包括手术切除、放疗和化疗等,并总结了这些方法在实际应用中的优缺点。此外,本文还对大熊猫睾丸癌的发病机制进行了深入探讨,涉及遗传因素、环境因素和内分泌紊乱等可能的触发因素。基于现有研究成果,本文提出了一些未来的研究方向,这将为大熊猫的健康管理和种群保护提供重要支持。总体而言,尽管大熊猫睾丸癌的研究取得了一定进展,但仍需进一步深入,以便为濒危大熊猫物种的医疗保健和繁殖提供更有力的科学依据。