Economidis George, Lynch Michelle, Taylor Sophia, Asare-Doku Winifred, Macpherson Georgina, Degenhardt Louisa, Farrell Michael, Santo Thomas
National Drug and Alcohol Research Centre, UNSW Sydney, Sydney, Australia.
Drug Alcohol Rev. 2025 Sep;44(6):1601-1640. doi: 10.1111/dar.14080. Epub 2025 Jun 25.
Kava is a plant-based drug central to many Pacific Island cultures, yet its physiological and psychological effects remain contested and poorly understood. Additionally, the broader social, economic, and policy consequences of kava trade and consumption are unclear. This paper systematically reviewed global literature on kava to clarify its role and potential impacts across these domains.
We conducted a systematic search of eight databases for records published between January 1980 and December 2022. Records on kava prevalence, social and cultural use, harms, benefits, economic impacts and policy reports were included. Data were narratively synthesised, combining qualitative and quantitative data extracted using a pre-designed template for each outcome, including a risk of bias evaluation.
We included 197 records across all domains. Most prevalence records used convenience samples in populations regularly consuming kava but with varying doses and periods. The harms and benefits of kava varied; its role in liver toxicity and anxiety reduction remains unclear. However, kava's social and cultural uses in recreational and traditional contexts and its economic importance in trade, distribution and sales across Pacific Islander countries were consistently reported.
Kava holds social and cultural significance and is an essential trading commodity for Pacific Islander countries. Additional high-quality studies with larger samples are necessary to better inform policies and regulations around kava's usage, distribution, and its potential harms and benefits.
卡瓦是一种源自植物的药物,在许多太平洋岛屿文化中占据核心地位,但其生理和心理影响仍存在争议且了解不足。此外,卡瓦贸易和消费所产生的更广泛的社会、经济和政策后果尚不明晰。本文系统回顾了关于卡瓦的全球文献,以阐明其在这些领域中的作用和潜在影响。
我们对八个数据库进行了系统检索,查找1980年1月至2022年12月期间发表的记录。纳入了关于卡瓦流行情况、社会和文化用途、危害、益处、经济影响及政策报告的记录。对数据进行了叙述性综合分析,结合使用预先设计的模板针对每个结果提取的定性和定量数据,包括偏倚风险评估。
我们纳入了所有领域的197条记录。大多数流行情况记录采用的是经常饮用卡瓦但剂量和饮用时长各异的人群中的便利样本。卡瓦的危害和益处各不相同;其在肝毒性和减轻焦虑方面的作用仍不明确。然而,卡瓦在娱乐和传统背景下的社会和文化用途以及其在太平洋岛国贸易、分销和销售中的经济重要性得到了一致报道。
卡瓦具有社会和文化意义,是太平洋岛国的一种重要贸易商品。需要开展更多高质量、大样本的研究,以便更好地为围绕卡瓦使用、分销及其潜在危害和益处的政策和法规提供信息。