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Bioactive Therapies for Degenerative Disc Disease: Challenges and Innovations.

作者信息

Fidai Alikhan B, Cardenas Ashley, Ikwuegbuenyi Chibuikem A, Robayo Anthony, Willett Noah, Hussain Ibrahim, Härtl Roger, Bonassar Lawrence J

机构信息

Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.

Department of Neurological Surgery, Och Spine at New York Presbyterian Hospital, Weill Cornell Medicine, New York, New York, USA.

出版信息

World Neurosurg. 2025 Jul;199:124132. doi: 10.1016/j.wneu.2025.124132. Epub 2025 Jun 2.

DOI:10.1016/j.wneu.2025.124132
PMID:40561644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12344652/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/234e/12344652/530ac26f9279/nihms-2098838-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/234e/12344652/530ac26f9279/nihms-2098838-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/234e/12344652/530ac26f9279/nihms-2098838-f0001.jpg

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World Neurosurg. 2025 Aug;200:124107. doi: 10.1016/j.wneu.2025.124107. Epub 2025 May 21.
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Outcomes following discectomy for lumbar disc herniation in patients with substantial back pain.
有严重背痛的腰椎间盘突出症患者行椎间盘切除术后的结果
J Neurosurg Spine. 2020 Jul 10;33(5):623-626. doi: 10.3171/2020.4.SPINE191382.
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Targeted CRISPR regulation of ZNF865 enhances stem cell cartilage deposition, tissue maturation rates, and mechanical properties in engineered intervertebral discs.靶向CRISPR对ZNF865的调控增强了工程化椎间盘中干细胞软骨沉积、组织成熟率和力学性能。
Acta Biomater. 2025 Jan 1;191:276-291. doi: 10.1016/j.actbio.2024.11.007. Epub 2024 Nov 8.
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Flexible support material maintains disc height and supports the formation of hydrated tissue engineered intervertebral discs in vivo.柔性支撑材料可维持椎间盘高度，并支持在体内形成水合组织工程化椎间盘。
JOR Spine. 2024 Aug 5;7(3):e1363. doi: 10.1002/jsp2.1363. eCollection 2024 Sep.
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