Wagner R F, Pellegrini J R, Delzell E
J Dermatol Surg Oncol. 1985 Nov;11(11):1097-102. doi: 10.1111/j.1524-4725.1985.tb01398.x.
It is established in the clinical literature that patients who develop specific types of malignancies are at an increased statistical risk for the development of a second primary malignancy. Previous studies have supported the theory that patients who develop primary cutaneous malignant melanoma (PCMM) have a greater risk for the development of a secondary primary noncutaneous malignancy (SPNM). Taken from the tumor registry of a community hospital, data for 504 consecutive patients (254 men and 250 women) with a diagnosis of PCMM were evaluated for the incidence of subsequent SPNM by comparing this series of patients to the general population of Connecticut. It was demonstrated that patients with PCMM had a significantly reduced incidence of SPNM (p = 0.002). Consideration should be given to possible biological and behavioral mechanisms which could explain the observed deficit.
临床文献表明，罹患特定类型恶性肿瘤的患者发生第二原发性恶性肿瘤的统计学风险会增加。先前的研究支持这样一种理论，即罹患原发性皮肤恶性黑色素瘤（PCMM）的患者发生继发性原发性非皮肤恶性肿瘤（SPNM）的风险更高。从一家社区医院的肿瘤登记处获取了504例连续诊断为PCMM的患者（254名男性和250名女性）的数据，通过将这组患者与康涅狄格州的普通人群进行比较，评估了后续SPNM的发生率。结果表明，PCMM患者的SPNM发生率显著降低（p = 0.002）。应考虑可能的生物学和行为机制，以解释观察到的差异。
