Cavaliere Gina, Costanzi Egidia, Cenci-Goga Beniamino, Misuraca Marco, Traina Giovanna
Department of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, Italy.
Department of Veterinary Medicine, University of Perugia, 06126 Perugia, Italy.
Biology (Basel). 2025 Jun 19;14(6):734. doi: 10.3390/biology14060734.
Histamine intolerance is a condition that occurs when there is an imbalance between the accumulation and degradation of histamine within the body. Excess histamine is metabolized and then degraded by two enzymes, of which the most abundant is the vesicular diamine oxidase (DAO). An imbalance or a state of dysbiosis of the intestinal microbiota has been observed in patients with histamine intolerance compared to healthy individuals. Studies indicate that the administration of bifidobacteria or lactobacilli alone or in mixtures can alter colonic microbiota populations and metabolic activities. The present study has evaluated the ability of a probiotic bacterial strain to stimulate the release of cellular DAO from an in vitro model of the human intestinal epithelial barrier. The results indicate that, under the experimental conditions used, probiotic strain LP115 has a significant stimulatory effect on DAO secretion in adenocarcinoma cell line HT-29.
组胺不耐受是一种在体内组胺积累与降解失衡时出现的病症。过量的组胺会被两种酶代谢并降解，其中最主要的是囊泡二胺氧化酶（DAO）。与健康个体相比，组胺不耐受患者肠道微生物群存在失衡或失调状态。研究表明，单独或混合施用双歧杆菌或乳酸杆菌可改变结肠微生物群的数量和代谢活性。本研究评估了一种益生菌菌株从人肠上皮屏障体外模型刺激细胞DAO释放的能力。结果表明，在所使用的实验条件下，益生菌菌株LP115对腺癌细胞系HT - 29中的DAO分泌具有显著的刺激作用。
