Chen Jun, Han Jiajun, Yang Zheng, Zhou Wenyue, He Yuyong, Chen Xingping, Li Xin, Zou Tiande, You Jinming
Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China.
Animals (Basel). 2025 Jun 10;15(12):1713. doi: 10.3390/ani15121713.
The use of in-feed antibiotics was banned in numerous countries within the animal production industry as a result of the emergence of antibiotic-resistant bacteria and the presence of residual antibiotics. Bacteriophages, which are viruses that infect host bacterial cells, are considered the natural predators of bacteria. Over the past two decades, bacteriophages have garnered increasing attention for their potential in controlling pathogenic bacteria in weaned piglets.
The aim of this overview was to update the progress of bacteriophage application in weaned piglets.
For the section on bacteriophage application in weaned piglets, a systematic search was performed to identify relevant articles published before June 2025 in databases such as Web of Science.
In this review, we provide a brief overview of bacteriophages, followed by a summary of the isolation of specific bacteriophages in weaned piglets. In addition, we have summarized the application progress of bacteriophages in weaned piglets, including the effects of oral administration or dietary supplementation with bacteriophages on growth performance, diarrhea characteristics, intestinal morphology, intestinal pH, nutrient digestibility, inflammatory response, intestinal barrier function, and intestinal microecology.
This updated overview novelly highlights the potential of bacteriophages as anti-pathogenic agents in mitigating infections caused by pathogenic bacteria in weaned piglets. This review could provide a scientific basis for controlling pathogenic bacteria infections in weaned piglets in the post-antibiotic era.
由于抗生素耐药菌的出现以及残留抗生素的存在，许多国家已禁止在动物生产行业中使用饲料中添加抗生素。噬菌体是感染宿主细菌细胞的病毒，被认为是细菌的天然捕食者。在过去二十年中，噬菌体在控制断奶仔猪病原菌方面的潜力越来越受到关注。
本综述的目的是更新噬菌体在断奶仔猪中应用的进展。
对于噬菌体在断奶仔猪中应用的部分，我们进行了系统检索，以识别在诸如科学网等数据库中2025年6月之前发表的相关文章。
在本综述中，我们简要概述了噬菌体，随后总结了断奶仔猪中特定噬菌体的分离情况。此外，我们还总结了噬菌体在断奶仔猪中的应用进展，包括口服或在日粮中添加噬菌体对生长性能、腹泻特征、肠道形态、肠道pH值、养分消化率、炎症反应、肠道屏障功能和肠道微生态的影响。
这一更新后的综述新颖地突出了噬菌体作为抗病原菌剂在减轻断奶仔猪病原菌感染方面的潜力。本综述可为抗生素后时代控制断奶仔猪病原菌感染提供科学依据。
