Li Yiguang, Luo Xin, Hu Rong, Tang Lifeng, Xiang Qi
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510632, China.
Biopharmaceutical R&D Center of Jinan University Co., Ltd., Guangzhou 510632, China.
Bioengineering (Basel). 2025 Jun 13;12(6):652. doi: 10.3390/bioengineering12060652.
This review addresses the exposure risks associated with the inhalation of aerosolized cosmetic products and explores the utility of lung organoids in assessing these risks. Aerosolized cosmetics such as sprays pose potential health hazards through inhalation, necessitating a thorough evaluation of exposure levels. Traditional methods for assessing inhalation risks have limitations, prompting the exploration of more sophisticated models. Lung organoids, three-dimensional structures derived from stem cells, offer a biologically relevant model for studying lung responses to inhaled substances. This review discusses the construction of lung organoids, their characteristics, and the advantages that they provide over conventional models. Furthermore, it examines existing studies that have employed lung organoids to evaluate the effects of cosmetic inhalation exposure, highlighting the potential of this approach to enhance the safety assessments of cosmetic products. We aim to establish lung organoids as a reliable tool for future research, ensuring the safety and regulatory compliance of cosmetics.
本综述探讨了吸入雾化化妆品所带来的暴露风险，并探索了肺类器官在评估这些风险方面的实用性。喷雾等雾化化妆品通过吸入会带来潜在的健康危害，因此有必要对暴露水平进行全面评估。传统的吸入风险评估方法存在局限性，这促使人们探索更复杂的模型。肺类器官是由干细胞衍生而来的三维结构，为研究肺部对吸入物质的反应提供了一个具有生物学相关性的模型。本综述讨论了肺类器官的构建、其特征以及相较于传统模型所具有的优势。此外，还审视了利用肺类器官评估化妆品吸入暴露影响的现有研究，突出了这种方法在加强化妆品安全评估方面的潜力。我们旨在将肺类器官确立为未来研究的可靠工具，确保化妆品的安全性并符合监管要求。
