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分数激光在痤疮瘢痕治疗中的应用——一项系统评价

The Use of a Fractional Laser in Acne Scar Treatment-A Systematic Review.

作者信息

Ptaszek Bartłomiej, Czernecka Marzena, Podsiadło Szymon

机构信息

Institute of Applied Sciences, University of Physical Culture in Krakow, 31-571 Krakow, Poland.

Faculty of Motor Rehabilitation, University of Physical Culture in Krakow, 31-571 Krakow, Poland.

出版信息

Life (Basel). 2025 Jun 4;15(6):915. doi: 10.3390/life15060915.

DOI:10.3390/life15060915
PMID:40566567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12194615/
Abstract

Acne scars are an unwanted reminder of past acne. They constitute a significant esthetic and psychosocial problem, negatively affecting the quality of life of patients. There are many methods used to treat acne scars. One of them is fractional CO laser treatment, which stimulates the skin to produce collagen. The main aim of this study was to verify, based on the available literature, the effectiveness of fractional CO laser treatment of acne scars and to determine the potential risk associated with the use of this therapeutic method. The literature review includes English-language articles selected using keywords and inclusion and exclusion criteria. In order to select appropriate sources, databases such as PubMed and Google Scholar were searched. The systematic review included seven studies that assessed the effectiveness of fractional CO laser therapy for acne scars. Most patients experienced a 30% to 70% improvement in the appearance of their scars. The most commonly reported adverse events during treatment were transient erythema, edema, and post-inflammatory hyperpigmentation, which resolved within a few weeks. Fractional CO laser therapy is an effective and safe treatment for acne scars. However, despite the abundance of evidence, there is a need for further studies focusing on long-term monitoring of patients.

摘要

痤疮疤痕是过去痤疮留下的令人烦恼的痕迹。它们构成了一个重大的美学和心理社会问题,对患者的生活质量产生负面影响。治疗痤疮疤痕有许多方法。其中之一是分次二氧化碳激光治疗,它能刺激皮肤产生胶原蛋白。本研究的主要目的是根据现有文献验证分次二氧化碳激光治疗痤疮疤痕的有效性,并确定与使用这种治疗方法相关的潜在风险。文献综述包括使用关键词以及纳入和排除标准筛选出的英文文章。为了选择合适的来源,检索了诸如PubMed和谷歌学术等数据库。系统评价纳入了七项评估分次二氧化碳激光治疗痤疮疤痕有效性的研究。大多数患者的疤痕外观改善了30%至70%。治疗期间最常报告的不良事件是短暂性红斑、水肿和炎症后色素沉着,这些在几周内就会消退。分次二氧化碳激光治疗是一种治疗痤疮疤痕有效且安全的方法。然而,尽管有大量证据,但仍需要进一步开展侧重于对患者进行长期监测的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/986b/12194615/37157cb1798a/life-15-00915-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/986b/12194615/37157cb1798a/life-15-00915-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/986b/12194615/37157cb1798a/life-15-00915-g001.jpg

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本文引用的文献

1
Combination of Fractional Microneedling Radiofrequency and Ablative Fractional Laser versus Ablative Fractional Laser Alone for Acne and Acne Scars.微针射频联合剥脱性点阵激光与单纯剥脱性点阵激光治疗痤疮及痤疮瘢痕的疗效比较
Yonsei Med J. 2023 Dec;64(12):721-729. doi: 10.3349/ymj.2023.0234.
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Methods for the Improvement of Acne Scars Used in Dermatology and Cosmetology: A Review.皮肤科和美容领域中用于改善痤疮瘢痕的方法:综述
J Clin Med. 2022 May 12;11(10):2744. doi: 10.3390/jcm11102744.
3
Evaluation of psychological well-being and social impact of atrophic acne scarring: A multinational, mixed-methods study.
萎缩性痤疮瘢痕的心理健康状况及社会影响评估:一项跨国混合方法研究。
JAAD Int. 2021 Dec 23;6:43-50. doi: 10.1016/j.jdin.2021.11.006. eCollection 2022 Mar.
4
Fractional CO Laser vs Fractional CO with Topical Platelet-rich Plasma in the Treatment of Acne Scars: A Split-face Comparison Trial.剥脱性二氧化碳激光联合外用富血小板血浆与单纯剥脱性二氧化碳激光治疗痤疮瘢痕的半脸对照试验
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Fractional carbon dioxide laser for the treatment of facial atrophic acne scars: prospective clinical trial with short and long-term evaluation.二氧化碳点阵激光治疗面部萎缩性痤疮瘢痕:短期和长期评估的前瞻性临床试验
Lasers Med Sci. 2017 Dec;32(9):2047-2054. doi: 10.1007/s10103-017-2322-7. Epub 2017 Sep 11.
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Efficacy of autologous platelet-rich plasma combined with fractional ablative carbon dioxide resurfacing laser in treatment of facial atrophic acne scars: A split-face randomized clinical trial.富自体血小板血浆联合剥脱性二氧化碳分次换肤激光治疗面部萎缩性痤疮瘢痕的疗效:一项半脸随机临床试验。
Indian J Dermatol Venereol Leprol. 2016 Mar-Apr;82(2):162-8. doi: 10.4103/0378-6323.174378.
7
Randomized clinical trial of CO₂ LASER pinpoint irradiation technique versus chemical reconstruction of skin scars (CROSS) in treating ice pick acne scars.二氧化碳激光精准照射技术与皮肤瘢痕化学重建术(CROSS)治疗冰锥型痤疮瘢痕的随机临床试验
J Cosmet Laser Ther. 2014 Jan;16(1):8-13. doi: 10.3109/14764172.2013.854633. Epub 2013 Dec 14.
8
Randomized clinical trial of CO2 laser pinpoint irradiation technique with/without needling for ice pick acne scars.二氧化碳激光精准照射技术联合/不联合针刺治疗冰锥型痤疮瘢痕的随机临床试验
J Cosmet Laser Ther. 2013 Jun;15(3):177-82. doi: 10.3109/14764172.2013.793584. Epub 2013 May 8.
9
Comparison of fractional erbium-doped yttrium aluminum garnet and carbon dioxide lasers in resurfacing of atrophic acne scars in Asians.比较铒石榴石激光和二氧化碳激光在亚洲人治疗萎缩性痤疮瘢痕中的疗效。
Dermatol Surg. 2013 Jan;39(1 Pt 1):111-20. doi: 10.1111/dsu.12030. Epub 2012 Dec 3.
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Comparison of Q-Switched 1064-nm Nd: YAG laser and fractional CO2 laser efficacies on improvement of atrophic facial acne scar.调Q开关1064纳米钕:钇铝石榴石激光与超脉冲二氧化碳激光改善面部萎缩性痤疮瘢痕疗效的比较
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