Kar Bikash R, Raj Chinmoy
Department of DVL, Institute of Medical Sciences and SUM Hospital, Siksha 'O' Anusandhan University, Bhubaneswar, Odisha, India.
J Cutan Aesthet Surg. 2017 Jul-Sep;10(3):136-144. doi: 10.4103/JCAS.JCAS_99_17.
It is a challenge to treat acne scars and a multimodal combination approach is necessary. While fractional CO lasers (FCLs) are an established treatment option, the role of platelet-rich plasma (PRP) in the treatment of acne scars is not established though it is being used extensively in other fields of medicine owing to its healing properties. We combined the two methods to assess the proposed synergistic action on acne scars.
To evaluate the effect of FCL alone vs FCL combined with PRP on the quality of acne scars.
This is a left-right split-face comparison study with 30 patients with moderate-to-severe acne scars. The patients underwent three sessions of FCL and FCL + topical PRP on right and left sides of the face, respectively, at monthly intervals.
There was significant improvement on both sides of the face (right side, = 0.001; left side, = 0.0001), but the difference between the right and the left sides of the face was not statistically significant ( = 0.2891). The symptoms of redness, edema, and pain on the treated areas with laser were significantly lesser on the FCL + PRP (left) side as compared to the FCL-only (right) side.
Both methods were effective in management of acne scars. Addition of PRP does not improve the scar quality; however, the downtime and inflammation associated with laser treatment gets significantly reduced on the PRP-treated side.
治疗痤疮疤痕是一项挑战，采用多模式联合方法很有必要。虽然分次二氧化碳激光（FCL）是一种既定的治疗选择，但富含血小板血浆（PRP）在痤疮疤痕治疗中的作用尚未明确，尽管因其愈合特性在其他医学领域被广泛应用。我们将这两种方法结合起来，以评估其对痤疮疤痕的协同作用。
评估单纯FCL与FCL联合PRP对痤疮疤痕质量的影响。
这是一项针对30例中重度痤疮疤痕患者的左右半脸对照研究。患者分别在面部右侧和左侧每月接受一次，共三次FCL治疗以及FCL + 局部PRP治疗。
面部两侧均有显著改善（右侧， = 0.001；左侧， = 0.0001），但面部左右两侧之间的差异无统计学意义（ = 0.2891）。与仅接受FCL治疗（右侧）的一侧相比，FCL + PRP治疗（左侧）的一侧激光治疗区域的发红、水肿和疼痛症状明显较轻。
两种方法对痤疮疤痕的治疗均有效。添加PRP并不能改善疤痕质量；然而，在PRP治疗侧，与激光治疗相关的停工期和炎症明显减少。
