Morooka T, Umeda A, Amako K
J Gen Microbiol. 1985 Aug;131(8):1973-80. doi: 10.1099/00221287-131-8-1973.
The colonization of the intestinal tract of suckling mice by Campylobacter jejuni was examined by orally challenging the mice with a wild-type strain and several nonmotile mutant strains which were isolated after treating the wild-type strain with mutagens. The wild-type strain had colonized the lower portion of the small intestine, the caecum and the colon 2 d after inoculation. Two nonmotile strains, one of which (M8) had lost all the flagellar structure including the filament, the hook and the basal structure, and the other (M1) which had lost only the filament region, were both cleared from the intestinal tract 2 d after challenge. Another nonmotile strain (M14), which had a complete flagellar structure like that of the wild-type strain, did not colonize and was cleared from the intestinal tract like the other nonmotile and nonflagellated strains. One atypically motile strain (M5), which had a shorter flagellar filament than that of the wild-type strain, colonized the intestinal tract only when mice were challenged with a large inoculum. None of the mice challenged with either the wild-type or any of the mutant strains showed signs of illness. We concluded that motility is an important factor in the colonization of the intestinal tract of suckling mice by C. jejuni.
通过用野生型菌株和几个经诱变剂处理野生型菌株后分离得到的非运动性突变菌株经口感染乳鼠，研究了空肠弯曲菌在乳鼠肠道中的定殖情况。接种后2天，野生型菌株定殖于小肠下部、盲肠和结肠。两个非运动性菌株，其中一个（M8）失去了包括鞭毛丝、钩和基部结构在内的所有鞭毛结构，另一个（M1）仅失去了鞭毛丝区域，在感染后2天均从肠道中清除。另一个非运动性菌株（M14）具有与野生型菌株一样完整的鞭毛结构，未定殖，并像其他非运动性和无鞭毛的菌株一样从肠道中清除。一个非典型运动性菌株（M5），其鞭毛丝比野生型菌株的短，只有在用大量接种物感染小鼠时才定殖于肠道。用野生型或任何突变菌株感染的小鼠均未表现出疾病迹象。我们得出结论，运动性是空肠弯曲菌在乳鼠肠道定殖中的一个重要因素。
