Malik Anku, Eggersdorfer Manfred, Trilok-Kumar Geeta
Institute of Home Economics, University of Delhi, India.
DSM Nutritional Products Ltd, Kaiseraugst, Switzerland.
Int J Vitam Nutr Res. 2021 Jun;91(3-4):356-369. doi: 10.1024/0300-9831/a000590. Epub 2019 May 24.
Vitamin E is a lipid soluble antioxidant which mainly circulates as α-tocopherol in the human plasma. Its deficiency is associated with ataxia, neuropathy, anaemia and several other health conditions. Although substantial data on vitamin E status has been published worldwide, there is paucity of data on the extent of deficiency from most Asian countries, including India. Part of the problem is lack of validated biomarkers for vitamin E and no consensus on cut offs for defining deficiency and sufficiency. Thus, interpretation of the data on the vitamin E status is difficult. Limited available data from 31 studies on vitamin E status in healthy people from Asia, the most populated continent, has been collated for the purpose of this review. Broadly, the results suggest inadequate vitamin E status in most age groups, with the prevalence of deficiency reaching 67%, 80%, 56% and 72% in infants, children and adolescents, adults, elderly and pregnant women, respectively, based on varying cut offs. The findings are not surprising as both, vitamin E intakes and its status have not received too much attention in the past. Lack of conclusive data accentuates the need for more research on the vitamin E status across all age groups and to define age, gender and physiological state specific cut offs for vitamin E levels.
维生素E是一种脂溶性抗氧化剂，在人体血浆中主要以α-生育酚的形式循环。其缺乏与共济失调、神经病变、贫血及其他多种健康状况相关。尽管全球已发表了大量关于维生素E状况的数据，但包括印度在内的大多数亚洲国家关于维生素E缺乏程度的数据却很少。部分问题在于缺乏经过验证的维生素E生物标志物，且对于定义缺乏和充足的临界值也未达成共识。因此，对维生素E状况数据的解读存在困难。为了本次综述，已整理了来自31项关于亚洲（人口最多的大陆）健康人群维生素E状况研究的有限可用数据。总体而言，结果表明大多数年龄组的维生素E状况不足，根据不同的临界值，婴儿、儿童和青少年、成年人、老年人及孕妇的维生素E缺乏患病率分别达到67%、80%、56%和72%。这些发现并不令人惊讶，因为过去维生素E的摄入量及其状况都未受到太多关注。缺乏确凿数据凸显了对所有年龄组的维生素E状况进行更多研究以及确定维生素E水平的年龄、性别和生理状态特定临界值的必要性。
