Eyraud Natacha, Mzali Fatima, Hemar Victor, Robert David, Paviot Camille, Touzalin Antoine, Isidore Alexandre, Vignon Guillaume, Violette Jérémie, Chrisment Delphine, Poirot-Mazères Stéphane, Barret Amaury, Morel Philippe, Mendes-Moreira Ana, Pereyre Sabine, Cazanave Charles, Vareil Marc-Olivier, Puges Mathilde
Infectious and Tropical Diseases Department, Bordeaux University Hospital, Bordeaux, France.
Bordeaux University, UMR CNRS 5234, Aquitaine Microbiologie, Bordeaux, France.
Open Forum Infect Dis. 2025 May 29;12(6):ofaf309. doi: 10.1093/ofid/ofaf309. eCollection 2025 Jun.
Data on "non-choleric spp." (NCV) infections remain scarce, despite their classification as emerging pathogens. Indeed, their incidence is increasing with global warming, as observed in North Atlantic countries. Furthermore, their prognosis is complicated by high morbidity and mortality rates.
We investigated the epidemiology of NCV infections in hospital, community, and environmental settings along the French West coastline. A retrospective multicenter study was carried out in 10 hospitals and 3 community laboratories between 2017 and 2020 in the Nouvelle-Aquitaine region to collect clinical data on all documented infections, which were later compared to data collected on environmental strains recovered concomitantly from the same coastal region.
A total of 223 cases were documented, suggesting that NCV infections are widely underestimated in France, as the number of patients included in this study in a single region exceeded the total cases reported by the French National Reference Center for species during the same period (202). Additionally, gastroenteritis caused by NCVs increased from .13% in 2017 to 0.39% in 2019. The most at-risk patients were immunocompromised or those with cancer. The clinical symptoms were mainly gastroenteritis or skin infections. The treatments prescribed did not align always with current recommendations and susceptibility to tetracycline, the recommended treatment, was never assessed. Antibiotic resistance seemed more common in environmental strains than in clinical strains, notably to aminoglycosides.
NCV infection incidence has been increasing in this Atlantic coastal region of France, and the high rates of antibiotic resistance among environmental strains are worrying.
尽管“非霍乱弧菌属”（NCV）感染被归类为新兴病原体，但其相关数据仍然稀少。事实上，正如在北大西洋国家所观察到的那样，随着全球变暖，它们的发病率正在上升。此外，其高发病率和死亡率使预后变得复杂。
我们调查了法国西部海岸线沿线医院、社区和环境中的NCV感染流行病学情况。2017年至2020年期间，在新阿基坦地区的10家医院和3个社区实验室开展了一项回顾性多中心研究，以收集所有已记录感染的临床数据，随后将这些数据与同时从同一沿海地区回收的环境菌株数据进行比较。
共记录了223例病例，这表明NCV感染在法国被广泛低估，因为仅一个地区纳入本研究的患者数量就超过了法国国家物种参考中心同期报告的病例总数（202例）。此外，由NCV引起的肠胃炎从2017年的0.13%增至2019年的0.39%。风险最高的患者是免疫功能低下者或癌症患者。临床症状主要为肠胃炎或皮肤感染。所开的治疗方法并不总是与当前建议一致，且从未评估过对推荐治疗药物四环素的敏感性。抗生素耐药性在环境菌株中似乎比在临床菌株中更为常见，尤其是对氨基糖苷类抗生素。
在法国的这个大西洋沿岸地区，NCV感染发病率一直在上升，环境菌株中抗生素耐药性的高发生率令人担忧。
