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Pseudohyponatremia: Mechanism, Diagnosis, Clinical Associations and Management.假性低钠血症：机制、诊断、临床关联及管理
J Clin Med. 2023 Jun 15;12(12):4076. doi: 10.3390/jcm12124076.
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The effect of haemolysis on the direct and indirect ion selective electrode measurement of sodium.溶血对钠离子直接和间接离子选择性电极测量的影响。
Ann Clin Biochem. 2021 May;58(3):190-195. doi: 10.1177/0004563220987593. Epub 2021 Jan 12.
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Hemolyzed specimens: a major challenge for emergency departments and clinical laboratories.溶血标本：急诊科和临床实验室面临的主要挑战。
Crit Rev Clin Lab Sci. 2011 May-Jun;48(3):143-53. doi: 10.3109/10408363.2011.600228.
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Pseudohyponatremia in a patient with HIV and hepatitis C coinfection.一名同时感染艾滋病毒和丙型肝炎患者的假性低钠血症
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严重溶血所致假性低钠血症

Pseudohyponatremia Caused by Severe Hemolysis.

作者信息

Yonemoto Hitoshi

机构信息

Infectious Disease, Yamato Takada Municipal Hospital, Yamatotakada, JPN.

出版信息

Cureus. 2025 May 26;17(5):e84824. doi: 10.7759/cureus.84824. eCollection 2025 May.

DOI:10.7759/cureus.84824
PMID:40568256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12188948/
Abstract

A 78-year-old man with influenza presented to the hospital. Initial blood tests revealed severe hemolysis accompanied by a decreased serum sodium concentration. However, repeat testing showed no hemolysis, and the serum sodium level was within the normal range. Notably, the serum sodium concentration in the initial sample, when measured using a blood gas analyzer, was also normal. These findings led to a diagnosis of pseudohyponatremia secondary to severe hemolysis. The underlying mechanisms of this condition are discussed herein.

摘要

一名78岁的流感患者入院。初步血液检查显示严重溶血，同时血清钠浓度降低。然而，重复检测未发现溶血，血清钠水平在正常范围内。值得注意的是，使用血气分析仪测量初始样本中的血清钠浓度时也是正常的。这些发现导致诊断为严重溶血继发的假性低钠血症。本文讨论了这种情况的潜在机制。