Jonker Sarah, Dalenberg Jelle R, Peretti Debora E, van der Stouwe A M Madelein, Tijssen Marina A J
Expertise Centre Movement Disorders Groningen, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, The Netherlands.
Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva CH-1211, Switzerland.
Brain Commun. 2025 Jun 18;7(3):fcaf227. doi: 10.1093/braincomms/fcaf227. eCollection 2025.
The pathophysiology and cerebellar role in essential tremor are not yet fully understood. Previous fludeoxyglucose positron emission tomography (FDG-PET) studies comparing glucose metabolism between essential tremor and healthy participants have led to few and inconsistent results. We aimed to examine changes in brain glucose metabolism in [F]FDG PET brain imaging in 19 right-handed essential tremor patients and compare them to 19 right-handed healthy participants using a voxel-based mass univariate analysis. The Montreal Cognitive Assessment and the Hospital Depression scale were used as covariates. In addition, the correlation between tremor severity as measured with the Fahn-Tolosa-Marin Tremor Rating Scale and brain glucose metabolism in essential tremor patients was assessed. Essential tremor patients showed significantly higher metabolism in the right dentate nucleus and, at a more liberal threshold, lower metabolism in the right parietal cortex. A positive correlation was detected between glucose metabolism in the left paracentral region and tremor severity, again at more liberal thresholding. Beyond the cerebello-thalamo-cortical circuit, the decreased activity in the right parietal areas in essential tremor patients may indicate that the sensorimotor integration is an important aspect of essential tremor pathophysiology. In conclusion, our findings show altered glucose metabolism within and beyond the cerebello-thalamo-cortical circuit.
原发性震颤的病理生理学及小脑作用尚未完全明确。以往比较原发性震颤患者与健康受试者葡萄糖代谢情况的氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）研究结果较少且不一致。我们旨在通过基于体素的全脑单变量分析，研究19例右利手原发性震颤患者[F]FDG PET脑成像中的脑葡萄糖代谢变化，并将其与19例右利手健康受试者进行比较。采用蒙特利尔认知评估量表和医院抑郁量表作为协变量。此外，评估了用法恩-托洛萨-马林震颤评定量表测量的震颤严重程度与原发性震颤患者脑葡萄糖代谢之间的相关性。原发性震颤患者右侧齿状核代谢显著升高，在较宽松的阈值下，右侧顶叶皮质代谢降低。在较宽松的阈值下，左侧中央旁区域的葡萄糖代谢与震颤严重程度呈正相关。除了小脑-丘脑-皮质环路外，原发性震颤患者右侧顶叶区域的活动减少可能表明感觉运动整合是原发性震颤病理生理学的一个重要方面。总之，我们的研究结果显示小脑-丘脑-皮质环路内外的葡萄糖代谢均发生了改变。
