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叶绿素介导的光动力失活：抑制作用中的剂量和时间依赖性

Chlorophyllin-Mediated Photodynamic Inactivation: Dosage and Time Dependency in the Inhibition of .

作者信息

Pohland Sarah, Vourvoutsiotou Jana, Brandtner Leah, Geißler David, Wiesmeth Selina, Scudlo Vanessa, Richter Peter, Burkovski Andreas, Lebert Michael

机构信息

Cell Biology Division, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.

Microbiology Division, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.

出版信息

Microorganisms. 2025 May 23;13(6):1189. doi: 10.3390/microorganisms13061189.

DOI:10.3390/microorganisms13061189
PMID:40572076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12195115/
Abstract

Photodynamic inactivation of bacteria offers a promising alternative to counteract the trend towards the development of resistance, which, if left uncontrolled, will lead to the death of 10 million people per year by 2050. Its advantage over antibiotics is the site-specific mode of action due to the photosensitizer (PS) and the low risk of developing resistance. This is primarily prevented by the damage of the bacteria, which also destroy internal structures such as nucleic acid, proteins, and lipids. A promising and still little-researched PS is chlorophyllin (CHL), a chlorophyll derivative. This study investigated its mode of action on growth using optical density (OD) measurements. It was shown that the PS is highly effective even at low concentrations and short irradiation durations. Here, 1 mg/L and an irradiation duration of 1 min were sufficient to inhibit the growth of the Gram-positive bacterium for several hours.

摘要

细菌的光动力失活为应对耐药性发展趋势提供了一种有前景的替代方法，若不加以控制，到2050年每年将导致1000万人死亡。它相对于抗生素的优势在于，由于光敏剂（PS）的作用具有位点特异性，且产生耐药性的风险较低。这主要是通过对细菌的损伤来防止的，这种损伤还会破坏诸如核酸、蛋白质和脂质等内部结构。一种有前景且仍未得到充分研究的光敏剂是叶绿素铜钠盐（CHL），一种叶绿素衍生物。本研究使用光密度（OD）测量法研究了其对生长的作用方式。结果表明，即使在低浓度和短照射时间下，该光敏剂也具有高效性。在此，1毫克/升的浓度和1分钟的照射时间足以抑制革兰氏阳性菌的生长达数小时。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/f5670a98bdfa/microorganisms-13-01189-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/f606a4efa2b3/microorganisms-13-01189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/92e7de4644c4/microorganisms-13-01189-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/97660fa99865/microorganisms-13-01189-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/b404d1e19123/microorganisms-13-01189-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/f11fc5f8509c/microorganisms-13-01189-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/c5cee550f4cc/microorganisms-13-01189-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/d123ca345c92/microorganisms-13-01189-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/b49bc642a267/microorganisms-13-01189-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/84e56c996965/microorganisms-13-01189-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/a607536f8d77/microorganisms-13-01189-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/f5670a98bdfa/microorganisms-13-01189-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/f606a4efa2b3/microorganisms-13-01189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/92e7de4644c4/microorganisms-13-01189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/9340f7145530/microorganisms-13-01189-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/97660fa99865/microorganisms-13-01189-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/b404d1e19123/microorganisms-13-01189-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/f11fc5f8509c/microorganisms-13-01189-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/c5cee550f4cc/microorganisms-13-01189-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/d123ca345c92/microorganisms-13-01189-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/b49bc642a267/microorganisms-13-01189-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/84e56c996965/microorganisms-13-01189-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/a607536f8d77/microorganisms-13-01189-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36aa/12195115/f5670a98bdfa/microorganisms-13-01189-g012.jpg

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本文引用的文献

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