National Centre for Biological Sciences (TIFR), Bengaluru 560065, India.
National Centre for Biological Sciences (TIFR), Bengaluru 560065, India.
Curr Opin Microbiol. 2023 Jun;73:102323. doi: 10.1016/j.mib.2023.102323. Epub 2023 May 4.
Cells across domains of life have dedicated pathways to sense and respond to DNA damage. These responses are broadly termed as DNA damage responses (DDRs). In bacteria, the best studied DDR is the Save our Soul (SOS) response. More recently, several SOS-independent DDRs have also been discovered. Studies further report diversity in the types of repair proteins present across bacterial species as well as differences in their mechanisms of action. Although the primary function of DDRs is preservation of genome integrity, the diverse organization, conservation, and function of bacterial DDRs raises important questions about how genome error correction mechanisms could influence or be influenced by the genomes that encode them. In this review, we discuss recent insights on three SOS-independent bacterial DDRs. We consider open questions in our understanding of how diversity in response and repair mechanisms is generated, and how action of these pathways is regulated in cells to ensure maintenance of genome integrity.
生命领域的细胞都有专门的途径来感知和响应 DNA 损伤。这些反应通常被称为 DNA 损伤反应（DDRs）。在细菌中，研究得最好的 DDR 是拯救我们的灵魂（SOS）反应。最近，也发现了几种 SOS 不依赖的 DDR。研究进一步报告了不同细菌物种中存在的修复蛋白的类型多样性，以及它们作用机制的差异。尽管 DDR 的主要功能是保持基因组完整性，但细菌 DDR 的多样化组织、保守性和功能提出了一个重要问题，即基因组纠错机制如何影响或被编码它们的基因组所影响。在这篇综述中，我们讨论了三种 SOS 不依赖的细菌 DDR 的最新研究进展。我们考虑了我们对响应和修复机制多样性的产生以及这些途径在细胞中的作用如何被调节以确保基因组完整性的理解中的一些开放性问题。
