Jabal Khadijah A, Pigott Maria, Sheridan Helen, Walsh John J
NatPro Centre, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, D02 PN40 Dublin, Ireland.
Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Molecules. 2025 Jun 17;30(12):2616. doi: 10.3390/molecules30122616.
species native to the Mediterranean basin are the principal that have found use in traditional medicine. Examples include treatments for urinary tract disorders, inflammatory conditions, gastrointestinal ailments and weight loss. This review critically evaluates the ethnobotanical usage, phytochemical profiles and pharmacological potential of the Mediterranean species, including L., L. and Salisb. A wide spectrum of bioactive secondary metabolites has been identified across these species, notably pentacyclic triterpenes (e.g., lupeol, ursolic acid and oleanolic acid) and polyphenolics (e.g., myricetin and quercetin glycosides). Extracts of these species have demonstrated antioxidant, anti-inflammatory, analgesic, antimicrobial and diuretic activities in vitro and/or in vivo, providing pharmacological support for traditional uses. Phytochemical profiles vary by species, plant part, geography and extraction technique. Filsuvez, comprising pentacyclic triterpenes from birch bark, has clinical approval for the treatment of partial thickness wounds associated with dystrophic and junctional epidermolysis bullosa. The undoubted reservoir of pentacyclic triterpenes and flavonoid glycosides in Mediterranean species warrants further comprehensive mechanistic studies, toxicological evaluations and clinical validation.
原产于地中海盆地的物种是在传统医学中得到应用的主要物种。例子包括用于治疗泌尿系统疾病、炎症性疾病、胃肠道疾病和减肥。本综述批判性地评估了地中海物种的民族植物学用途、植物化学概况和药理潜力，包括[具体物种1]、[具体物种2]和[具体物种3]。在这些物种中已鉴定出多种生物活性次生代谢物，特别是五环三萜（如羽扇豆醇、熊果酸和齐墩果酸）和多酚类（如杨梅素和槲皮素糖苷）。这些物种的提取物在体外和/或体内已表现出抗氧化、抗炎、镇痛、抗菌和利尿活性，为传统用途提供了药理学支持。植物化学概况因物种、植物部位、地理位置和提取技术而异。Filsuvez由来自桦树皮的五环三萜组成，已获得临床批准用于治疗与营养不良性和交界性大疱性表皮松解症相关的浅度伤口。地中海物种中五环三萜和黄酮糖苷的无疑储备值得进一步进行全面的机制研究、毒理学评估和临床验证。
