Camlik Gamze, Bilakaya Besa, Güven Gökçe Karaotmarlı, Akkol Esra Küpeli, Degim Zelihagül, Sobarzo-Sánchez Eduardo, Degim Ismail Tuncer
Department of Pharmaceutical Technology, Faculty of Pharmacy, Biruni University, Istanbul 34015, Türkiye.
Biruni University Research Center (B@MER), Biruni University, Istanbul 34015, Türkiye.
Pharmaceuticals (Basel). 2025 May 22;18(6):767. doi: 10.3390/ph18060767.
Carbon quantum dots (CQDs) are carbon-based structures with particle sizes ranging from 1 to 10 nm. They can be prepared using various carbon sources, including those doped with heteroatoms. CQDs exhibit unique optoelectronic properties, high photostability, low toxicity, and exceptional biocompatibility. It was aimed to produce CQDs from active pharmaceutical ingredients (APIs). This study introduces a novel class of CQDs synthesized directly from APIs, which we term "Quantum Drugs" (Q-Drugs). We present several APIs alongside detailed methods for Q-Drug synthesis and characterization. We describe the necessary structural properties for forming Q-Drugs and provide the values for particle size, polydispersity index, and zeta potential that were obtained from various drug molecules. The particle sizes were determined with the size of 7.360 ± 0.030 nm and 10.000 ± 0.022 nm; polydispersity indexes of 10.500 ± 1.230 and 32.610 ± 1.401; and zeta potentials of -3.400 ± 0.054 mV and -40.000 ± 0.142 mV, respectively using different APIs. This study successfully demonstrated the synthesis and characterization of Q-Drugs, a novel class of CQD derived from APIs. The results provide valuable data on the physicochemical properties of these Q-Drugs, paving the way for further investigation into their potential applications.
碳量子点(CQDs)是一类碳基结构,其粒径范围为1至10纳米。它们可以使用各种碳源制备,包括那些掺杂有杂原子的碳源。碳量子点具有独特的光电特性、高光稳定性、低毒性和出色的生物相容性。本研究旨在从活性药物成分(APIs)制备碳量子点。这项研究引入了一类直接由活性药物成分合成的新型碳量子点,我们将其称为“量子药物”(Q-Drugs)。我们展示了几种活性药物成分以及量子药物合成和表征的详细方法。我们描述了形成量子药物所需的结构特性,并提供了从各种药物分子获得的粒径、多分散指数和zeta电位值。使用不同的活性药物成分测定的粒径分别为7.360±0.030纳米和10.000±0.022纳米;多分散指数分别为10.500±1.230和32.610±1.401;zeta电位分别为-3.400±0.054毫伏和-40.000±0.142毫伏。这项研究成功地证明了量子药物(一类源自活性药物成分的新型碳量子点)的合成和表征。研究结果提供了关于这些量子药物物理化学性质的有价值数据,为进一步研究它们的潜在应用铺平了道路。