Schultz R E, Varello M A, Tsou K C, Wein A J, Murphy J J
J Urol. 1985 Dec;134(6):1133-6. doi: 10.1016/s0022-5347(17)47658-0.
Flow cytometry can differentiate benign from malignant lesions of the prostate through deoxyribonucleic acid distribution analysis. A method has been developed that permits simultaneous cytometric determination of deoxyribonucleic acid and acid phosphatase activity in the cell cycle compartments of prostatic biopsy specimens. Histograms of prostatic carcinoma reveal higher acid phosphatase activity and greater deoxyribonucleic acid content in the S and S + G2/M populations than the histograms representing benign lesions. This compartmental difference may have prognostic usefulness.
流式细胞术可通过脱氧核糖核酸分布分析区分前列腺的良性和恶性病变。现已开发出一种方法，可同时对前列腺活检标本细胞周期各时相中的脱氧核糖核酸和酸性磷酸酶活性进行细胞测定。前列腺癌的直方图显示，与代表良性病变的直方图相比，S期和S + G2/M期群体中的酸性磷酸酶活性更高，脱氧核糖核酸含量更多。这种区域差异可能具有预后价值。
