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Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study.治疗阿尔茨海默病阻塞性睡眠呼吸暂停的认知效应：一项随机对照研究。
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Changes in dreaming induced by CPAP in severe obstructive sleep apnea syndrome patients.持续气道正压通气对重度阻塞性睡眠呼吸暂停综合征患者梦境的影响
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The effect of sleep-disordered breathing on stages of sleep in patients with Alzheimer's disease.睡眠呼吸障碍对阿尔茨海默病患者睡眠阶段的影响。
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Continuous positive airway pressure reduces subjective daytime sleepiness in patients with mild to moderate Alzheimer's disease with sleep disordered breathing.持续气道正压通气可减轻轻度至中度阿尔茨海默病合并睡眠呼吸障碍患者的日间主观嗜睡。
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Effect of continuous positive airway pressure versus supplemental oxygen on sleep quality in obstructive sleep apnea: a placebo-CPAP-controlled study.持续气道正压通气与补充氧气对阻塞性睡眠呼吸暂停患者睡眠质量的影响：一项安慰剂对照的持续气道正压通气研究。
Sleep. 2006 Apr;29(4):564-71. doi: 10.1093/sleep/29.4.564.
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Adherence to continuous positive airway pressure treatment in patients with Alzheimer's disease and obstructive sleep apnea.阿尔茨海默病合并阻塞性睡眠呼吸暂停患者对持续气道正压通气治疗的依从性。
Am J Geriatr Psychiatry. 2006 Feb;14(2):176-80. doi: 10.1097/01.JGP.0000192484.12684.cd.
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Sleep-disordered breathing and agitation in institutionalized adults with Alzheimer disease.患有阿尔茨海默病的机构养老成年人的睡眠呼吸障碍与激越
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A randomized, controlled trial of 1 week of continuous positive airway pressure treatment on quality of life.一项关于持续气道正压通气治疗1周对生活质量影响的随机对照试验。
Heart Lung. 2003 Jan-Feb;32(1):52-8. doi: 10.1067/mhl.2003.8.
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Effect of continuous positive airway pressure on sleep architecture in the sleep apnea-hypopnea syndrome: a randomized controlled trial.持续气道正压通气对睡眠呼吸暂停低通气综合征睡眠结构的影响：一项随机对照试验。
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持续气道正压通气可加深阿尔茨海默病合并阻塞性睡眠呼吸暂停患者的睡眠。

Continuous positive airway pressure deepens sleep in patients with Alzheimer's disease and obstructive sleep apnea.

机构信息

Department of Medicine, University of California San Diego, La Jolla, Ca 92093-0733, USA.

出版信息

Sleep Med. 2009 Dec;10(10):1101-6. doi: 10.1016/j.sleep.2008.12.016. Epub 2009 Aug 20.

DOI:10.1016/j.sleep.2008.12.016
PMID:19699148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2783482/
Abstract

OBJECTIVE

Patients with Alzheimer's disease (AD) and obstructive sleep apnea (OSA) experience disrupted sleep. This study examined the effect of continuous positive airway pressure (CPAP) on sleep parameters in AD patients with OSA.

METHODS

A randomized placebo-controlled trial of 3 weeks of therapeutic CPAP (tCPAP) vs. 3 weeks placebo CPAP (pCPAP) followed by 3 weeks tCPAP in patients with AD and OSA. Polysomnography data from screening after one night and after 3 weeks of treatment were analyzed. Records were scored for percent of each sleep stage, total sleep time (TST), sleep efficiency (SE), sleep period (SP), time in bed (TIB), sleep onset (SO), wake time after sleep onset (WASO), and arousals. A randomized design comparing one night of pCPAP to tCPAP and a paired analysis combining 3 weeks of tCPAP were performed.

RESULTS

Fifty-two participants (mean age=77.8 years, SD=7.3) with AD and OSA were included. After one treatment night, the tCPAP group had significantly less % Stage 1 (p=0.04) and more % Stage 2 sleep (p=0.02) when compared to the pCPAP group. In the paired analysis, 3 weeks of tCPAP resulted in significant decreases in WASO (p=0.005), % Stage 1 (p=0.001), arousals (p=0.005), and an increase in % Stage 3 (p=0.006).

CONCLUSION

In mild to moderate AD patients with OSA, the use of tCPAP resulted in deeper sleep after just one night, with improvements maintained for 3 weeks.

摘要

目的

患有阿尔茨海默病（AD）和阻塞性睡眠呼吸暂停（OSA）的患者睡眠质量较差。本研究旨在探讨持续气道正压通气（CPAP）治疗对伴有 OSA 的 AD 患者睡眠参数的影响。

方法

对患有 AD 和 OSA 的患者进行了为期 3 周的治疗性 CPAP（tCPAP）与安慰剂 CPAP（pCPAP）的随机、安慰剂对照试验，随后进行了 3 周的 tCPAP 治疗。对经过一夜和 3 周治疗后的筛查多导睡眠图数据进行了分析。记录了各睡眠阶段的百分比、总睡眠时间（TST）、睡眠效率（SE）、睡眠周期（SP）、卧床时间（TIB）、睡眠潜伏期（SO）、睡眠潜伏期后觉醒时间（WASO）和觉醒次数。进行了比较一夜 pCPAP 与 tCPAP 的随机设计和结合 3 周 tCPAP 的配对分析。

结果

52 名患有 AD 和 OSA 的参与者（平均年龄=77.8 岁，SD=7.3）被纳入研究。经过一夜的治疗后，与 pCPAP 组相比，tCPAP 组的 Stage 1 百分比显著降低（p=0.04），Stage 2 睡眠百分比显著升高（p=0.02）。在配对分析中，3 周的 tCPAP 治疗可显著降低 WASO（p=0.005）、Stage 1 百分比（p=0.001）、觉醒次数（p=0.005），并增加 Stage 3 百分比（p=0.006）。

结论

在轻度至中度 AD 合并 OSA 的患者中，仅使用 tCPAP 一夜后即可使睡眠更深，3 周后效果持续。