Zuo Cuihua, Xue Junhao, Yuan Cao
School of Mathematics and Computer Science, Wuhan Polytechnic University, Wuhan, 430048, China.
Sci Rep. 2025 Jul 2;15(1):22459. doi: 10.1038/s41598-025-06529-1.
The early diagnosis of brain tumors is crucial for patient prognosis, and medical imaging techniques such as MRI and CT scans are essential tools for diagnosing brain tumors. However, high-quality medical image data for brain tumors is often scarce and difficult to obtain, which hinders the development and application of medical image analysis models. With the advancement of artificial intelligence, particularly deep learning technologies in the field of medical imaging, new concepts and tools have been introduced for the early diagnosis, treatment planning, and prognosis evaluation of brain tumors. To address the challenge of imbalanced brain tumor datasets, we propose a novel data augmentation technique based on a diffusion model, referred to as the Multi-Channel Fusion Diffusion Model(MCFDiffusion). This method tackles the issue of data imbalance by converting healthy brain MRI images into images containing tumors, thereby enabling deep learning models to achieve better performance and assisting physicians in making more accurate diagnoses and treatment plans. In our experiments, we used a publicly available brain tumor dataset and compared the performance of image classification and segmentation tasks between the original data and the data enhanced by our method. The results show that the enhanced data improved the classification accuracy by approximately 3% and the Dice coefficient for segmentation tasks by 1.5%-2.5%. Our research builds upon previous work involving Denoising Diffusion Implicit Models (DDIMs) for image generation and further enhances the applicability of this model in medical imaging by introducing a multi-channel approach and fusing defective areas with healthy images. Future work will explore the application of this model to various types of medical images and further optimize the model to improve its generalization capabilities. We release our code at https://github.com/feiyueaaa/MCFDiffusion.
脑肿瘤的早期诊断对患者预后至关重要,而诸如MRI和CT扫描等医学成像技术是诊断脑肿瘤的重要工具。然而,高质量的脑肿瘤医学图像数据往往稀缺且难以获取,这阻碍了医学图像分析模型的开发和应用。随着人工智能的发展,特别是医学成像领域的深度学习技术,已引入了用于脑肿瘤早期诊断、治疗规划和预后评估的新概念和工具。为应对脑肿瘤数据集不平衡的挑战,我们提出了一种基于扩散模型的新型数据增强技术,称为多通道融合扩散模型(MCFDiffusion)。该方法通过将健康的脑MRI图像转换为包含肿瘤的图像来解决数据不平衡问题,从而使深度学习模型能够取得更好的性能,并协助医生做出更准确的诊断和治疗计划。在我们的实验中,我们使用了一个公开可用的脑肿瘤数据集,并比较了原始数据与我们方法增强后的数据在图像分类和分割任务上的性能。结果表明,增强后的数据使分类准确率提高了约3%,分割任务的Dice系数提高了1.5%-2.5%。我们的研究基于先前涉及用于图像生成的去噪扩散隐式模型(DDIM)的工作,并通过引入多通道方法以及将缺陷区域与健康图像融合,进一步提高了该模型在医学成像中的适用性。未来的工作将探索该模型在各种类型医学图像上的应用,并进一步优化模型以提高其泛化能力。我们在https://github.com/feiyueaaa/MCFDiffusion上发布了我们的代码。