Sancho-Cantus David, Sanchis Elena Sanchis, Casani-Cubel Julia, Privado Jesús, Escriba Jesús, Carriquí-Suárez Ana Belén, Benlloch María, Cerón José Joaquín, Rubio Camila Peres, Cubero-Plazas Laura, de la Rubia Ortí José Enrique
Department of Nursing, Catholic University of Valencia Saint Vicent Martyr, 46001, Valencia, Spain.
General Health Psychologist, CapSa Centre Déspecialitats, Benifaió, 46450, Valencia, Spain.
Sci Rep. 2025 Jul 1;15(1):21145. doi: 10.1038/s41598-025-07729-5.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by high levels of inflammation and oxidative stress, predominantly affecting males, particularly those between the ages of 50 and 65 years. It is characterised by progressive loss of motor neurones, leading to both motor and non-motor symptoms, such as sleep impairment, diagnosed in most patients, which adversely affects their quality of life. Therefore, this study aimed to determine the predictive role of antioxidant capacity, psychological distress, age, and sex on sleep impairment in an adult population of patients with ALS. A descriptive, quantitative, cross-sectional study was conducted using a sample of 74 patients diagnosed with bulbar or spinal ALS. To assess sleep disturbances in these patients, the Pittsburgh sleep quality index (PSQI), epworth sleepiness scale (ESS), and Insomnia severity index were used. Additionally, plasma antioxidant capacity was analysed using the total antioxidant capacity (TEAC), Cupric Ion reducing antioxidant capacity (CUPRAC), and ferric reducing power (FRAP). Anxiety and depression measures were used to measure psychological distress. Men exhibited a higher antioxidant status (lower oxidative stress) than women, and higher antioxidant capacity was associated with fewer sleep impairments (β = -0.43). Psychological distress may increase sleep impairment (β = -0.26). Furthermore, older individuals experienced less sleep impairment (β = -0.27), while sex had minimal influence on sleep deterioration, although it appears that men had fewer disturbances (β = -0.12). Having a higher antioxidant status, lower psychological distress, being male, and being older seem to act as predictors of reduced sleep impairment in ALS. Specifically, these four predictors account for 32% of sleep deterioration.Clínical trial registration: The present descriptive, quantitative, cross-sectional study was part of a clinical trial involving ALS patients, registered under the number NCT04654689 ( https://clinicaltrials.gov/study/NCT04654689#wrapper ).
肌萎缩侧索硬化症（ALS）是一种神经退行性疾病，其特征是高水平的炎症和氧化应激，主要影响男性，尤其是年龄在50至65岁之间的男性。它的特点是运动神经元逐渐丧失，导致运动和非运动症状，如睡眠障碍，大多数患者都有这种症状，这对他们的生活质量产生了不利影响。因此，本研究旨在确定抗氧化能力、心理困扰、年龄和性别对成年ALS患者睡眠障碍的预测作用。采用描述性、定量、横断面研究方法，对74例被诊断为延髓或脊髓性ALS的患者进行了抽样调查。为了评估这些患者的睡眠障碍，使用了匹兹堡睡眠质量指数（PSQI）、爱泼华嗜睡量表（ESS）和失眠严重程度指数。此外，还使用总抗氧化能力（TEAC）、铜离子还原抗氧化能力（CUPRAC）和铁还原能力（FRAP）分析血浆抗氧化能力。使用焦虑和抑郁测量方法来评估心理困扰。男性的抗氧化状态（较低的氧化应激）高于女性，较高的抗氧化能力与较少的睡眠障碍相关（β = -0.43）。心理困扰可能会增加睡眠障碍（β = -0.26）。此外，年龄较大的个体睡眠障碍较少（β = -0.27），而性别对睡眠恶化的影响最小，尽管似乎男性的睡眠障碍较少（β = -0.12）。较高的抗氧化状态、较低的心理困扰、男性以及年龄较大似乎是ALS患者睡眠障碍减少的预测因素。具体而言，这四个预测因素占睡眠恶化的32%。临床试验注册：本描述性、定量、横断面研究是一项涉及ALS患者的临床试验的一部分，注册号为NCT04654689（https://clinicaltrials.gov/study/NCT04654689#wrapper）。
