Zhang Yong, Bao Fangfang, Dong Feifan, Yu Gongqi, Tian Hongqing
Dermatology Hospital of Shandong First Medical University, Jinan, Shandong, China.
Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
BMC Infect Dis. 2025 Jul 1;25(1):884. doi: 10.1186/s12879-025-11261-2.
Talaromyces wortmannii is a ubiquitous saprophytic fungus found in soil, plants, and marine organisms. Infections caused by T. wortmannii in humans are rarely reported, however, a recent case of skin mycosis attributed to this fungus highlights its potential to cause infections under certain conditions. Therefore, studying the biological characteristics of T. wortmannii is crucial for the prevention and control of dermatomycosis.
T. wortmannii was incubated on different medium and at various temperatures, gathered pertinent data on colony growth and conduct an analysis of its growth characteristics. The Sensititre YeastOne and CLSI M38 method was used to determine the minimum inhibitory concentrations (MICs) of amphotericin B, 5-flucytosine, anidulafungin, caspofungin, micafungin, fluconazole, itraconazole, posaconazole, voriconazole and Terbinafine. Finally, the in vivo virulence of T. wortmannii were investigated using Galleria mellonella as an infection model.
The characteristic of T.wortmannii included septate hyphae, occasionally fragmented with varying diameters. Velvety colonies with dense sporulation were observed, grow fastest at 32 °C and displayed a radial growth pattern with a centrally elevated morphology and a slightly depressed margin. The MICs of amphotericin B, itraconazole, posaconazole and voriconazole were relatively low, suggesting potential clinical efficacy. A greater number of deaths occurred at higher inoculum levels. Both the T.wortmannii clinical strain F22-1-C5 and standard strain CGMCC3.17703 exhibits virulence towards the larvae.
T. wortmannii can cause human infections. Amphotericin B, itraconazole, posaconazole, and voriconazole may be effective for treatment of such infectoins.
疣孢漆斑菌是一种广泛存在于土壤、植物和海洋生物中的腐生真菌。由疣孢漆斑菌引起的人类感染鲜有报道，然而，最近一例归因于该真菌的皮肤真菌病病例凸显了其在某些条件下引起感染的可能性。因此，研究疣孢漆斑菌的生物学特性对于皮肤真菌病的预防和控制至关重要。
将疣孢漆斑菌接种于不同培养基并置于不同温度下培养，收集有关菌落生长的相关数据并分析其生长特性。采用Sensititre YeastOne和CLSI M38方法测定两性霉素B、5-氟胞嘧啶、阿尼芬净、卡泊芬净、米卡芬净、氟康唑、伊曲康唑、泊沙康唑、伏立康唑和特比萘芬的最低抑菌浓度（MIC）。最后，以大蜡螟作为感染模型研究疣孢漆斑菌的体内毒力。
疣孢漆斑菌的特征包括有隔菌丝，偶尔有不同直径的片段。观察到菌落呈天鹅绒状，产孢密集，在32℃下生长最快，呈放射状生长模式，中央隆起，边缘略凹陷。两性霉素B、伊曲康唑、泊沙康唑和伏立康唑的MIC相对较低，表明可能具有临床疗效。接种量较高时死亡数量更多。疣孢漆斑菌临床菌株F22-1-C5和标准菌株CGMCC3.17703对幼虫均具有毒力。
疣孢漆斑菌可引起人类感染。两性霉素B、伊曲康唑、泊沙康唑和伏立康唑可能对治疗此类感染有效。
