Cai Rushuang, Li Chunying, Zhao Yong, Yuan Haisheng, Zhang Xiaomeng, Liang Aihua, Yi Yan
State Key Laboratory for Quality Ensurance and Sustainable use of Dao-Di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Chin Med. 2025 Jul 1;20(1):95. doi: 10.1186/s13020-025-01150-w.
Diabetic kidney disease (DKD) is a severe complication of diabetes and a leading cause of end-stage renal disease (ESRD). It is characterized by a complex pathogenesis that involves genetic, epigenetic, metabolic, and multifactorial elements. Current therapeutic approaches for DKD have significant limitations. In contrast, Traditional Chinese Medicine (TCM), with its personalized treatment based on syndrome differentiation, shows potential to modulate multiple pathological pathways implicated in DKD. This review provides a detailed examination of DKD pathogenesis and the progress in TCM research, offering valuable insights for DKD treatment research and clinical practice.
糖尿病肾病（DKD）是糖尿病的一种严重并发症，也是终末期肾病（ESRD）的主要原因。其发病机制复杂，涉及遗传、表观遗传、代谢和多因素等方面。目前DKD的治疗方法存在显著局限性。相比之下，中医基于辨证论治的个体化治疗显示出调节DKD相关多种病理途径的潜力。本文综述详细探讨了DKD的发病机制以及中医研究进展，为DKD治疗研究和临床实践提供了有价值的见解。
