Salama Iman I, Sami Samia M, Salama Somaia I, Abdel-Latif Ghada A, Aboulghate Ahmed, Raslan Hala M, Mohsen Amira, Rasmy Hanaa, Ibrahim Mona Hamed, Ganem Mona Mf, Abdelmohsen Aida M, El-Etreby Lobna A, Ibrahim Nihad A, Fouad Walaa A, El-Deeb Sherif E
Community Medicine Research Department, National Research Center, Cairo, 12622, Egypt.
Child Health Department, National Research Center, Cairo, 12622, Egypt.
Future Sci OA. 2023 Mar 9;9(1):FSO835. doi: 10.2144/fsoa-2022-0060. eCollection 2023 Jan.
Assessing impact of lifestyle modification on Type 2 diabetes mellitus (T2DM) glycemic control and cognitive function.
SUBJECTS & METHODS: Prospective study was conducted on T2DM patients (92 patients as interventional group and 92 patients conventional therapy).
After 6 months, significant improvements of HbA1c, oxidant and antioxidant, lipid profile, and cognitive function among only the interventional group (p < 0.05). Using logistic analysis, conventional therapy, DM duration >10 years, lower education, HbA1c baseline >7 were significant predictive risks for uncontrolled DM (AOR 4.2, 2.9, 2.7 and 2.2, respectively). While, conventional therapy, baseline mild cognitive impairment (MCI) and females were significant risks for MCI (AOR 11.5, 10.8 and 4.8, respectively).
Lifestyle modification is a very important for glycemic control and cognitive function.: NCT04891887 (ClinicalTrials.gov).
评估生活方式改变对2型糖尿病（T2DM）血糖控制和认知功能的影响。
对T2DM患者进行前瞻性研究（92例患者作为干预组，92例患者接受常规治疗）。
6个月后，仅干预组的糖化血红蛋白、氧化剂和抗氧化剂、血脂谱及认知功能有显著改善（p<0.05）。采用逻辑分析，常规治疗、糖尿病病程>10年、低教育水平、糖化血红蛋白基线>7是糖尿病控制不佳的显著预测风险因素（比值比分别为4.2、2.9、2.7和2.2）。而常规治疗、基线轻度认知障碍（MCI）和女性是发生MCI的显著风险因素（比值比分别为11.5、10.8和4.8）。
生活方式改变对血糖控制和认知功能非常重要。：NCT04891887（ClinicalTrials.gov）
