Zhang Yiyi, Zhang Haibo, Ma Chengyuan, Yang Yihang, Mo Xuan, Shi Yuan, Yin Zhijia, Li Hong, Sun Lin
Henan Key Laboratory of Polyoxometalate Chemistry, School of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, China.
School of Pharmacy, Henan University, Kaifeng, Henan 475004, China.
Food Chem. 2025 Nov 15;492(Pt 1):145351. doi: 10.1016/j.foodchem.2025.145351. Epub 2025 Jun 28.
Rapid and accurate detection of hydrogen peroxide (HO) and ascorbic acid (AA) in food industry is critical to human health. Herein, a novel Ce-based polyoxometalate [Ce(HO)][Cu(HO)(2,6-pdca)]H[SiWO]·5HO (Ce-POM) (2,6-Hpdca = 2,6-pyridine-dicarboxylic acid) was designed and loaded onto Cu-based benzene-1,3,5-tricarboxylate (CuBTC) to obtain Ce-POM/CuBTC, which can catalyze HO to oxidize 3,3',5,5'-tetramethylbenzidine (TMB) to blue ox-TMB, while AA can reduce ox-TMB. Consequently, a dual-function colorimetric detection system was established with detection limits of 0.45 μM (HO) and 2.63 μM (AA), and linear ranges of 1-80 μM (HO) and 5-400 μM (AA). We further developed a smartphone-assisted paper-based device (PAD) using Ce-POM/CuBTC for on-site detection. Additionally, the mice skin toxicity study showed that Ce-POM/CuBTC had no adverse effects on the skin, body weight and important organs of mice, confirming its good biosafety. The colorimetric system was successfully applied to real sample detection, demonstrating the application potential of rare earth POMs composites in food safety.
快速准确地检测食品工业中的过氧化氢（HO）和抗坏血酸（AA）对人类健康至关重要。在此，设计了一种新型的铈基多金属氧酸盐[Ce(HO)][Cu(HO)(2,6 - pdca)]H[SiWO]·5HO（Ce - POM）（2,6 - Hpdca = 2,6 - 吡啶二甲酸）并负载到铜基金属有机框架材料苯 - 1,3,5 - 三羧酸酯（CuBTC）上，得到Ce - POM/CuBTC，其可催化HO将3,3',5,5' - 四甲基联苯胺（TMB）氧化为蓝色的氧化态TMB（ox - TMB），而AA可将ox - TMB还原。因此，建立了一种双功能比色检测系统，其对HO的检测限为0.45 μM，对AA的检测限为2.63 μM，线性范围分别为1 - 80 μM（HO）和5 - 400 μM（AA）。我们进一步开发了一种使用Ce - POM/CuBTC的智能手机辅助纸质检测装置（PAD）用于现场检测。此外，小鼠皮肤毒性研究表明Ce - POM/CuBTC对小鼠的皮肤、体重和重要器官没有不良影响，证实了其良好的生物安全性。该比色系统成功应用于实际样品检测，证明了稀土多金属氧酸盐复合材料在食品安全方面的应用潜力。
