Buskard N A, Galton D A, Goldman J M, Kohner E M, Grindle C F, Newman D L, Twinn K W, Lowenthal R M
Can Med Assoc J. 1977 Jul 23;117(2):135-7.
Two patients with Waldenström's macroglobulinemia (WM), which had become resistant to cytotoxic drugs, were treated for features of the hyperviscosity syndrome by repeated plasma exchange with the continuous-flow blood-cell separator over periods of 36 and 28 months, respectively. After four initial weekly plasma exchanges the procedure was carried out every 4 to 6 weeks and both patients tolerated it well. Relative viscosity of the serum was maintained within the normal range in one patient, and both patients remained free of symptoms of the hyperviscosity syndrome. The results suggest that treatment of WM by long-term "maintenance" plasma exchange alone should be considered in any patient with complications due to chemotherapy or whose disease fails to respond to chemotherapy.
两名对细胞毒性药物产生耐药性的华氏巨球蛋白血症（WM）患者，分别通过连续流式血细胞分离器进行了36个月和28个月的重复血浆置换，以治疗高黏滞综合征的症状。在最初每周进行4次血浆置换后，该程序每4至6周进行一次，两名患者均耐受良好。其中一名患者的血清相对黏度维持在正常范围内，两名患者均未出现高黏滞综合征的症状。结果表明，对于任何因化疗出现并发症或疾病对化疗无反应的患者，应考虑单独采用长期“维持性”血浆置换治疗WM。
